Blood purification membrane, method for manufacturing blood purification membrane, and dialysis device

Patent metadata

Field	Value
Publication number	US-2016199789-A1
Application number	US-201414913698-A
Country	US
Kind code	A1
Filing date	Aug 25, 2014
Priority date	Aug 26, 2013
Publication date	Jul 14, 2016
Grant date	—

Abstract

A blood purification membrane capable of adsorbing creatinine which is a uremic toxin in the blood and purifying the blood, the blood purification membrane including fibers and particles adhered to the aforementioned fibers, wherein the aforementioned fibers are composed of a polymer insoluble in water, the aforementioned particles contain SiO 2 and Al 2 O 3 , and pores capable of incorporating at least a portion of the aforementioned uremic toxin are provided in the aforementioned particles.

First claim

1 . A blood purification membrane capable of adsorbing creatinine which is a uremic toxin in the blood and purifying the blood, the blood purification membrane comprising:
fibers; and particles adhered to said fibers, wherein said fibers comprise a polymer insoluble in water, said particles include SiO 2 and Al 2 O 3 , and pores capable of incorporating at least a portion of said uremic toxin are provided in said particles.

2 . The blood purification membrane according to claim 1 ,
wherein an SiO 2 /Al 2 O 3 molar ratio of said particles is equal to or more than 18 and equal to or less than 240.

3 . The blood purification membrane according to claim 1 , wherein said particles are zeolite or a zeolite composite.

4 . The blood purification membrane according to claim 1 , wherein said particles are particles having a maximum diameter of 5 μm or less.

5 . The blood purification membrane according to claim 1 ,
wherein said polymer is any one selected from the group consisting of an ethylene-vinyl alcohol copolymer (EVAL), polyvinylpyrrolidone (PVP), polyhydroxyethyl methacrylate (PHEMA), and polyvinyl alcohol (PVA).

6 . The blood purification membrane according to claim 1 , wherein a diameter of said fibers is at least 100 nm and not more than 1,000 nm.

7 . The blood purification membrane according to claim 1 , wherein the thickness is equal to or more than 10 nm.

8 . The blood purification membrane according to claim 1 , wherein said particles are fixed to said polymer while the surface thereof is coated with said polymer.

9 . A method for manufacturing a blood purification membrane, the method comprising:
a step of dispersing a hydrophilic polymer and particles including SiO 2 and Al 2 O 3 and provided with pores capable of incorporating at least a portion of creatinine which is a uremic toxin, in a solvent, thereby preparing a dispersion liquid of the particles and the hydrophilic polymer; and a step of producing the blood purification membrane by spinning a yarn from said dispersion liquid through an electrospinning method and coagulating the yarn, the blood purification membrane capable of adsorbing creatinine as a uremic toxin in the blood and purifying the blood, which comprises fibers and particles adhered to said fibers, wherein said fibers comprise a polymer insoluble in water, said particles include SiO 2 and Al 2 O 3 , and said particles are provided with pores capable of incorporating at least a portion of said uremic toxin.

10 . A dialysis device comprising:
a cylinder; a plurality of thin cylinders filled inside said cylinder by aligning the axial direction; a first lid portion for closing a first end side of said cylinder; a second lid portion for closing a second end side of said cylinder; a first tube joint portion provided in said first lid portion; and a second tube joint portion provided in said second lid portion, wherein an opening of said first tube joint portion is in communication with an opening of said second tube joint portion only through the inside of said plurality of thin cylinders, and said thin cylinders are formed by the blood purification membrane according to claim 1 .

11 . The dialysis device according to claim 10 , further comprising:
a third tube joint portion provided in said cylinder; and a fourth tube joint portion provided in said cylinder, wherein an opening of said third tube joint portion is in communication with an opening of said fourth tube joint portion only through a gap between an inner surface of said cylinder and an outer surface of said plurality of thin cylinders.

12 . A dialysis device comprising:
a cylinder; a plurality of thin cylindrical portions formed inside said cylinder by aligning the axial direction; a first lid portion for closing a first end side of said cylinder; a second lid portion for closing a second end side of said cylinder; a first tube joint portion provided in said first lid portion; and a second tube joint portion provided in said second lid portion, wherein an opening of said first tube joint portion is in communication with an opening of said second tube joint portion only through the inside of said plurality of thin cylindrical portions, and the blood purification membrane according to claim 1 is filled between said cylinder and said plurality of thin cylindrical portions.

Assignees

• Nat Inst For Materials Science
• Nat Inst Of Materials Science

Inventors

• Ebara Mitsuhiro
• NAMEKAWA Koki
• Aoyagi Takao

Classifications

• A61P7/08

  Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock (artificial tears A61P27/04) · CPC title

• A61P13/02

  of urine or of the urinary tract, e.g. urine acidifiers · CPC title

• B01D69/04

  Tubular membranes · CPC title

• B29K2029/04

  PVOH, i.e. polyvinyl alcohol (B29K2031/04 takes precedence) · CPC title

• B01D69/08

  Hollow fibre membranes (manufacture of hollow fibres D01D5/24, D01F1/08) · CPC title