Polymer materials for delivery of short-chain fatty acids to the intestine for applications in human health and treatment of disease

Patent metadata

Field	Value
Publication number	US-11633486-B2
Application number	US-201816605449-A
Country	US
Kind code	B2
Filing date	Apr 17, 2018
Priority date	Apr 17, 2017
Publication date	Apr 25, 2023
Grant date	Apr 25, 2023

Abstract

Provided herein are polymer materials that find use in, for example, delivery of short-chain fatty acids. In particular, polymers are provided that form stable nanoscale structures and release their payload, for example, by cleavage of a covalent bond (e.g., via hydrolysis or enzymatic cleavage). The polymers are useful, for example, for delivery of payloads (e.g., SCFAs) to the intestine for applications in health and treatment of disease, and have broad applicability in diseases linked to changes in the human microbiota including inflammatory, autoimmune, allergic, metabolic, and central nervous system diseases, among others.

First claim

What is claimed is:

1. A composition comprising a block copolymer having the structure:

wherein a and b are independently 1-1000.

2. A composition comprising a random copolymer having the structure:

wherein each Y is independently selected from (i) the side chain:

and (ii) the side chain:

3. A composition comprising a block copolymer having the structure:

wherein a and b are independently 1-1000.

4. A composition comprising a random copolymer having the structure:

wherein each Y is independently selected from (i) the side chain:

and (ii) the side chain:

5. A composition comprising a block copolymer having the structure:

wherein a and b are independently 1-1000.

6. A composition comprising a random copolymer having the structure:

wherein each Y is independently selected from (i) the side chain:

and (ii) the side chain:

7. The composition of claim 1 , wherein the copolymer is a block copolymer and comprises formula (VI):

wherein a and b are independently 1-1000.

8. The composition of claim 2 , wherein the copolymer is a random copolymer has the structure:

wherein each Y is independently selected from (i) the side chain of polyHPMA:

and (ii) the side chain of poly(2-butanoyloxyethyl methacrylamide):

9. The composition of claim 3 , comprising a block copolymer having the structure:

wherein a and b are independently 1-1000.

10. The composition of claim 4 , wherein the copolymer is a random copolymer and has the structure:

wherein each Y is independently selected from (i) the side chain of polyHPMA:

and (ii) the side chain of poly(2-(4-butanoyloxybenzoyloxy)ethyl methacrylate):

11. The composition of claim 5 , comprising a block copolymer having the structure:

wherein a and b are independently 1-1000.

12. The composition of claim 6 , comprising a random copolymer having the structure:

wherein each Y is independently selected from (i) the side chain of polyHPMA:

and (ii) the side chain of poly(2-(4-butanoyloxybenzoyloxy)ethyl methacrylamide):

Assignees

• Univ Chicago

Inventors

• Hubbell Jeffrey A
• Wang Ruyi
• Wilson D Scott
• Nagler Cathryn R
• Plunkett Catherine

Classifications

• A61K47/6933

  the polymer being obtained by reactions only involving carbon to carbon, e.g. poly(meth)acrylate, polystyrene, polyvinylpyrrolidone or polyvinylalcohol · CPC title

• A61K47/6909

  Micelles formed by phospholipids · CPC title

• A61K47/6907

  the form being a microemulsion, nanoemulsion or micelle · CPC title

• C08F2438/03

  Use of a di- or tri-thiocarbonylthio compound, e.g. di- or tri-thioester, di- or tri-thiocarbamate, or a xanthate as chain transfer agent, e.g . Reversible Addition Fragmentation chain Transfer [RAFT] or Macromolecular Design via Interchange of Xanthates [MADIX] · CPC title

• A61K47/58 Primary

  obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin · CPC title