Resin composition-filled syringe, and production method and preservation method for same

Patent metadata

Field	Value
Publication number	US-11623813-B2
Application number	US-202017435198-A
Country	US
Kind code	B2
Filing date	Feb 6, 2020
Priority date	Mar 29, 2019
Publication date	Apr 11, 2023
Grant date	Apr 11, 2023

Abstract

There is provided a syringe filled with a resin composition which prevents a barrel cap from being detached due to temperature change during storage or during transportation, a production method thereof, and a storage method thereof. This syringe filled with the resin composition includes a syringe having a syringe barrel, a resin composition filling the syringe barrel, a plunger inserted in the syringe barrel, a barrel cap blocking an opening of the syringe barrel, and a spatial part between the plunger and the barrel cap in the syringe barrel. The pressure of the spatial part in a frozen state is 50 kPa to 92 kPa.

First claim

The invention claimed is:

1. A syringe filled with a resin composition, comprising:
the syringe having a syringe barrel;
the resin composition filling the syringe barrel;
a plunger inserted into the syringe barrel;
a barrel cap blocking an opening of the syringe barrel; and
a spatial part between the plunger and the barrel cap in the syringe barrel,
wherein a pressure of the spatial part in a frozen state is 50 kPa to 92 kPa; and
a viscosity of the resin composition of less than 200 Pa·s measured at 25° C. and a rotational speed of 50 rpm and the viscosity of the resin composition of 200 Pa·s or more measured at 25° C. and a rotational speed of 10 rpm, using a rotary viscometer, are in a range of 2.5 Pa·s to 650 Pa·s.

2. The syringe filled with the resin composition according to claim 1 ,
wherein a filling amount of the resin composition is 10% to 95% of an internal capacity of the syringe.

3. The syringe filled with the resin composition according to claim 1 ,
wherein the resin composition contains at least one resin selected from epoxy resin and acrylic resin.

4. The syringe filled with the resin composition according to claim 1 ,
wherein thixotropic indices TI1 to TI3 of the resin composition measured under any of conditions (1) to (3) below are in a range of 0.4 to 4.0,

(1) Thixotropic index TI1 is a ratio between a viscosity at 5 rpm and the viscosity at 50 rpm, when the viscosity measured at 25° C. and 50 rpm using a rotary viscometer is in a range of not less than 2.5 Pa·s and less than 20 Pa·s,
(2) Thixotropic index TI2 is a ratio between the viscosity at 5 rpm and the viscosity at 50 rpm, when the viscosity measured at 25° C. and 50 rpm using a rotary viscometer is in a range of not less than 20 Pa·s and less than 200 Pa·s, and
(3) Thixotropic index TI3 is a ratio between the viscosity at 1 rpm and the viscosity at 10 rpm, when the viscosity measured at 25° C. and 10 rpm using a rotary viscometer is in a range of 200 Pa·s or more and 1,000 Pa·s or less.

5. The syringe filled with the resin composition according to claim 1 ,
wherein the syringe is made from polypropylene or polyethylene.

6. The syringe filled with the resin composition according to claim 1 ,
wherein the syringe has an internal capacity of 1 cm 3 to 600 cm 3 .

7. The syringe filled with the resin composition according to claim 1 , which is used for freezing.

8. A storage method of the syringe filled with the resin composition, comprising storing the syringe filled with the resin composition according to claim 1 at a temperature of −80° C. to 0° C.

9. A production method of a syringe filled with a resin composition, comprising:
a step of preparing the syringe filled with the resin composition having a spatial part between a plunger and a barrel cap in a syringe barrel, by filling the syringe barrel having the plunger inserted therein with the resin composition and blocking an opening of the syringe barrel with the barrel cap;
a step of freezing the syringe filled with the resin composition at a temperature of −80° C. to 0° C.; and
a step of reducing a pressure of the spatial part of the frozen syringe filled with the resin composition to 50 kPa to 92 kPa while holding the frozen syringe filled with the resin composition under a reduced pressure environment of 50 kPa to 92 kPa,
wherein a viscosity of the resin composition of less than 200 Pa·s measured at 25° C. and a rotational speed of 50 rpm and the viscosity of the resin composition of 200 Pa·s or more measured at 25° C. and a rotational speed of 10 rpm, using a rotary viscometer, are in a range of 2.5 Pa·s to 650 Pa·s.

10. The production method of the syringe filled with the resin composition according to claim 9 ,
wherein the step of reducing the pressure of the spatial part of the frozen syringe comprises reducing the pressure of the spatial part of the frozen syringe in a state where the syringe is frozen at the temperature of −80° C. to 0° C.

11. The production method of the syringe filled with the resin composition according to claim 9 ,
wherein a time during which the syringe filled with the resin composition is held under the reduced pressure environment is 30 minutes or more.

12. The production method of the syringe filled with the resin composition according to claim 9 ,
wherein a filling amount of the resin composition into the syringe barrel is 10% to 95% of an internal capacity of the syringe.

Assignees

• Namics Corp

Inventors

• MYODO Hiroki
• Hoshiyama Masaaki

Classifications

• B65D83/765

  the piston being a follower-piston and the dispensing means comprising a hand-operated pressure device at the opposite part of the container · CPC title

• B65D83/767

  the piston having an integrated dispensing opening (B65D83/762 takes precedence) · CPC title

• B65D83/763 Primary

  the piston being actuated by a reciprocating axial motion of a shaft which engages the piston, e.g. using a ratchet mechanism · CPC title

• B65D83/76 Primary

  for dispensing fluent contents by means of a piston · CPC title

• A61M5/24

  Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic {(ampoules or carpules A61J1/06)} · CPC title