Drug Reconstitution System

Patent metadata

Field	Value
Publication number	US-2016015900-A1
Application number	US-201314377585-A
Country	US
Kind code	A1
Filing date	Mar 8, 2013
Priority date	Mar 8, 2012
Publication date	Jan 21, 2016
Grant date	—

Abstract

A system including an adapter ( 14 ) for sequential engagement with a cartridge ( 18 ) containing a first substance and a vial ( 16 ) containing a second substance is disclosed. The adapter is configured to first engage with the vial and subsequently engage with the cartridge such that the cartridge is in fluid communication with the vial via the adapter. The system includes a latch member ( 150 ) engageable with a portion of the cartridge. A plunger rod ( 44 ) includes a protrusion ( 50 ) and is adapted to communicate with the latch member, the plunger rod being transitionable from a disengaged position, in which the protrusion of the plunger rod is disengaged from the latch member and the latch member is locked to the cartridge, to an engaged position, in which the protrusion is engaged with the latch member and the latch member is unlocked from the cartridge and locked to the plunger rod.

First claim

What is claimed is:

1 . A system comprising:
a cartridge holder having a cartridge holder distal end, a cartridge holder proximal end, and a sidewall extending therebetween and defining a chamber having an interior adapted to receive a cartridge therein; a stopper slidably disposed within an interior of the cartridge; and a latch member engageable with a portion of the cartridge holder and a portion of a plunger rod, wherein the plunger rod is engageable with a portion of the stopper and adapted to communicate with the latch member, the plunger rod comprising a protrusion, wherein the plunger rod is transitionable from a disengaged position, in which the protrusion of the plunger rod is disengaged from the latch member and the latch member is locked to the cartridge holder, to an engaged position, in which the protrusion is engaged with the latch member and the latch member is unlocked from the cartridge holder and locked to the plunger rod.

2 . The system of claim 1 , wherein the plunger rod further comprises a plunger rod distal end engageable with the portion of the stopper and a plunger rod proximal end, the protrusion extending from the plunger rod adjacent the plunger rod proximal end.

3 . The system of claim 1 , wherein with the plunger rod in the disengaged position, the latch member is locked to the cartridge holder proximal end.

4 . The system of claim 3 , wherein the stopper is slidably disposed within the interior of the chamber of the cartridge between a first position adjacent the cartridge holder proximal end and a second position adjacent the cartridge holder distal end.

5 . The system of claim 4 , wherein with the stopper in the first position the plunger rod is in the disengaged position.

6 . The system of claim 4 , wherein with the stopper in the second position the plunger rod is in the engaged position.

7 . The system of claim 1 , wherein a portion of the plunger rod is sized for movement within the interior of the chamber of the cartridge from the disengaged position to the engaged position.

8 . The system of claim 1 , further comprising a first substance contained within the chamber of the cartridge holder.

9 . A system comprising:
a cartridge holder having a cartridge holder distal end, a cartridge holder proximal end, and a sidewall extending therebetween and defining a cartridge chamber; a first substance contained within the cartridge chamber; a stopper slidably disposed within the cartridge chamber; a latch member engageable with a portion of the cartridge holder and a portion of a plunger rod, wherein the plunger rod is engageable with a portion of the stopper and adapted to communicate with the latch member, the plunger rod comprising a protrusion, wherein the plunger rod is transitionable from a disengaged position, in which the protrusion of the plunger rod is disengaged from the latch member and the latch member is locked to the cartridge holder, to an engaged position, in which the protrusion is engaged with the latch member and the latch member is unlocked from the cartridge holder and locked to the plunger rod; a vial defining a vial chamber; a second substance contained within the vial chamber; and an adapter having a first end adapted to engage the vial and a second end adapted to engage the cartridge holder after engagement with the vial.

10 . A system comprising:
a cartridge having a cartridge distal end, a cartridge proximal end, and a sidewall extending therebetween and defining a cartridge chamber; a first substance contained within the cartridge chamber; a vial defining a vial chamber; a second substance contained within the vial chamber; and an adapter adapted for sequential engagement with the vial and the cartridge.

11 . The system of claim 10 , wherein the adapter is adapted to first engage with the vial.

12 . The system of claim 11 , wherein with the vial engaged with the adapter, the adapter is adapted to engage with the cartridge such that the cartridge chamber is in fluid communication with the vial chamber via the adapter.

13 . The system of claim 12 , further comprising an actuation member adapted to expel the first substance from the cartridge chamber to the vial chamber via the adapter.

14 . The system of claim 13 , wherein the actuation member comprises:
a stopper slidably disposed within the cartridge chamber between a first position adjacent the cartridge proximal end and a second position adjacent the cartridge distal end; and a plunger rod having a plunger rod distal end engageable with a portion of the stopper, a plunger rod proximal end, and a portion of the plunger rod sized for movement within the cartridge chamber to actuate the stopper between the first position and the second position.

15 . The system of claim 14 , wherein actuation of the stopper from the first position to the second position by the plunger rod expels the first substance from the cartridge chamber to the vial chamber via the adapter.

16 . The system of claim 10 , wherein the first substance comprises a diluent.

17 . The system of claim 11 , wherein the second substance comprises a powder.

18 . A system comprising:
a cartridge holder having a cartridge holder distal end, a cartridge holder proximal end, and a sidewall extending therebetween and defining a chamber having an interior adapted to receive a cartridge therein; a stopper slidably disposed within the interior of the chamber of the cartridge holder between a first position adjacent the cartridge holder proximal end and a second position adjacent the cartridge holder distal end; and a locking member connected to the cartridge holder and adapted to prevent the stopper from sliding out of the cartridge holder.

19 . The system of claim 18 , wherein:
the stopper defines a stopper outer diameter; and the locking member defines a locking member inner diameter, the locking member inner diameter less than the stopper outer diameter, thereby the locking member provides a physical barrier preventing the stopper from sliding out of the cartridge holder.

20 . The system of claim 18 , wherein the locking member is connected adjacent to the cartridge proximal end.

21 . The system of claim 19 , further comprising a plunger rod having a plunger rod distal end engageable with a portion of the stopper, a plunger rod proximal end, and a deformable restraining member transitionable between a deformed position to an undeformed position, a portion of the plunger rod sized for movement within the interior of the chamber of the cartridge holder to actuate the stopper between the first position and the second position.

22 . The system of claim 21 , wherein with the plunger rod in an initial position the locking member deforms the restraining member of the plunger rod so that the plunger rod is capable of actuating the stopper from the first position to the second position.

23 . The system of claim 22 , wherein after the plunger rod actuates the stopper from the first position to the second position, as the plunger rod returns the stopper from the second position back to the first position and the restraining member of the plunger rod is advanced beyond the locking member, the restraining member of the plunger rod moves to its undeformed position and locks to the locking member, thereby the locking member prevents the plunger rod from actuating the stopper again from the first position to the second position.

Assignees

• Becton Dickinson Co

Inventors

• Cronenberg Richard
• Wu Haiming

Classifications

• A61M5/2448

  comprising means for injection of two or more media, e.g. by mixing · CPC title

• A61M2202/064

  Powder · CPC title

• A61J1/2048 Primary

  Connecting means · CPC title

• A61M5/31596

  comprising means for injection of two or more media, e.g. by mixing · CPC title

• A61M5/19

  having more than one chamber {, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly (surgical glue applicators A61B17/00491)} · CPC title