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Process for the synthesis of n-substituted lactams and amides
US11618732B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11618732-B2 |
| Application number | US-202017115396-A |
| Country | US |
| Kind code | B2 |
| Filing date | Dec 8, 2020 |
| Priority date | Dec 11, 2019 |
| Publication date | Apr 4, 2023 |
| Grant date | Apr 4, 2023 |
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- Title
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Abstract
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A process for the synthesis of N-alkylated lactams via reductive alkylation. The process of the present disclosure may be conducted by the addition of an aldehyde to a lactam in the presence of a catalyst under a reducing atmosphere.
First claim
Opening claim text (preview).
What is claimed is: 1. A process for preparing a substituted lactam, comprising: reacting caprolactam with an alkylating agent selected from paraformaldehyde, formaldehyde, and acetaldehyde; in the presence of: a catalyst; hydrogen; and optionally, process solvents, a total content of the process solvents of less than 1500 ppm, to form water and an N-substituted lactam selected from the group consisting of N-methylcaprolactam and N-ethylcaprolactam. 2. The process of claim 1 , wherein the total content of process solvents is less than 1000 ppm. 3. The process of claim 1 , wherein the catalyst is a palladium catalyst. 4. The process of claim 1 , wherein the reacting step is carried out at a temperature from 50° C. to 200° C. 5. The process of claim 1 , wherein the reacting step is carried out in the presence of a hydrogen atmosphere at a pressure of 100 to 200 psi. 6. The process of claim 1 , wherein the N-substituted lactam is N-methylcaprolactam. 7. The process of claim 1 , wherein the N-substituted lactam is N-ethylcaprolactam. 8. The process of claim 1 , wherein the N-substituted lactam is obtained at a yield of greater than 90%.
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Classifications
with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom · CPC title
attached in position 2 · CPC title
- C07D223/04Primary
with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms · CPC title
Oxygen or sulfur atoms · CPC title
Palladium · CPC title
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- What does patent US11618732B2 cover?
- A process for the synthesis of N-alkylated lactams via reductive alkylation. The process of the present disclosure may be conducted by the addition of an aldehyde to a lactam in the presence of a catalyst under a reducing atmosphere.
- Who is the assignee on this patent?
- Advansix Resins & Chemicals Llc, AdvanSix Resins & Chemical LLC
- What technology area does this patent fall under?
- Primary CPC classification C07D223/04. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 04 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).