Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US-10253018-B2 · Apr 9, 2019 · US
Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US11560368B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11560368-B2 |
| Application number | US-202117197399-A |
| Country | US |
| Kind code | B2 |
| Filing date | Mar 10, 2021 |
| Priority date | May 12, 2017 |
| Publication date | Jan 24, 2023 |
| Grant date | Jan 24, 2023 |
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- Title
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- Abstract
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Abstract
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The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, ester, stereoisomer, tautomer, solvate, hydrate, or combination thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcohol steatohepatitis disease (NASH).
First claim
Opening claim text (preview).
What is claimed: 1. A pharmaceutical composition comprising a compound selected from the compounds set forth in the table below, Com- pound Structure 5a 6a 7a 24a 25a 28a 30a 32a 33a 49a 51a 53a 55a 58a 61a or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient. 2. The pharmaceutical composition of claim 1 , wherein the compound has the structure 3. The pharmaceutical composition of claim 1 , wherein the compound has the structure 4. The pharmaceutical composition of claim 1 , wherein the compound has the structure 5. A method for treating an ASK-1 mediated disease or condition in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the pharmaceutical composition of claim 2 . 6. A method for treating an ASK-1 mediated disease or condition in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the pharmaceutical composition of claim 3 . 7. A method for treating an ASK-1 mediated disease or condition in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the pharmaceutical composition of claim 4 . 8. A method for treating an ASK-1 mediated disease or condition in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of the pharmaceutical composition of claim 1 .
Assignees
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Classifications
containing three or more hetero rings · CPC title
- C07D401/14Primary
containing three or more hetero rings · CPC title
containing three or more hetero rings · CPC title
linked by a chain containing hetero atoms as chain links · CPC title
containing three or more hetero rings · CPC title
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- What does patent US11560368B2 cover?
- The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, ester, stereoisomer, tautomer, solvate, hydrate, or combination thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which associated with autoimmune disorders, neurodegenerative disorders,…
- Who is the assignee on this patent?
- Enanta Pharm Inc
- What technology area does this patent fall under?
- Primary CPC classification C07D401/14. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Jan 24 2023 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).