Compositions and methods for managing or improving bone disorders, joint disorders, cartilage disorders, or a combination thereof

Patent metadata

Field	Value
Publication number	US-11554153-B2
Application number	US-202016812899-A
Country	US
Kind code	B2
Filing date	Mar 9, 2020
Priority date	Jun 16, 2014
Publication date	Jan 17, 2023
Grant date	Jan 17, 2023

Abstract

Compositions and methods for bone health, cartilage health or both, are disclosed that include preparing and utilizing a mixture of at least one Morus extract enriched for one or more prenylated flavonoids, at least one Scutellaria extract enriched for one or more free-B-ring flavonoids, and at least one Acacia extract enriched for one or more flavans.

First claim

We claim:

1. A method for supporting or managing bone health, cartilage health or both in a mammal, comprising administering an effective amount of a composition, wherein the composition comprising a mixture of at least one Morus extract enriched for one or more prenylated flavonoids, at least one Scutellaria extract enriched for one or more free-B-ring flavonoids, and at least one Acacia extract enriched for one or more flavans, wherein the Morus extract, the Scutellaria extract, and the Acacia extract are blended in a 1.3:1:1 weight ratio.

2. The method for supporting or managing bone health, cartilage health or both in a mammal of claim 1 , wherein the Morus extract is from Morus alba , the Scutellaria extract is from Scutellaria baicalensis , and the Acacia extract is from Acacia catechu.

3. The method for supporting or managing bone health, cartilage health or both in a mammal of claim 1 , wherein the Acacia extract comprises 0.01% to 99.9% flavans.

4. The method for supporting or managing bone health, cartilage health or both in a mammal of claim 1 , wherein the Morus extract comprises 0.1% to 49.9% prenylated flavonoids.

5. The method for supporting or managing bone health, cartilage health or both in a mammal of claim 1 , wherein the Scutellaria extract comprises 0.01% to 99.9% free-B-ring flavonoids.

6. The method for supporting or managing bone health, cartilage health or both in a mammal of claim 1 , wherein the one or more prenylated flavonoids comprises is Albanin G, Kuwanon G, Morusin, or any combination thereof.

7. The method for supporting or managing bone health, cartilage health or both in a mammal of claim 1 , wherein the one or more flavans comprises catechin, epicatechin, or a combination thereof.

8. The method for supporting or managing bone health, cartilage health or both in a mammal of claim 1 , wherein the composition additionally comprises a glucosamine-type compound.

9. The method for supporting or managing bone health, cartilage health or both in a mammal of claim 8 , wherein the glucosamine-type compound comprises glucosamine sulfate, glucosamine hydrochloride, N-acetylglucosamine, chondroitin sulfate methylsulfonylmethane, and hyaluronic acid.

10. The method for supporting or managing bone health, cartilage health or both in a mammal of claim 1 , wherein the composition further comprises a pharmaceutically or nutraceutically acceptable carrier, diluent, or excipient, wherein the pharmaceutical or nutraceutical formulation comprises from about 0.5 weight percent (wt %) to about 90 wt % of active ingredients of the extract mixture.

11. The method for supporting or managing bone health, cartilage health or both in a mammal of claim 10 , wherein the composition is formulated as a tablet, hard capsule, softgel capsule, powder, or granule.

12. A method for supporting or managing bone health, cartilage health or both in a mammal, comprising administering an effective amount of a composition, wherein the composition comprising a mixture of at least one Morus extract enriched for one or more prenylated flavonoids, at least one Scutellaria extract enriched for one or more free-B-ring flavonoids, and at least one Acacia extract enriched for one or more flavans, wherein the Morus extract, the Scutellaria extract, and the Acacia extract are blended in a 0.410:0.308:0.282 weight ratio.

Assignees

• Unigen Inc

Inventors

• Jia Qi
• Jiao Ping
• Yimam Mesfin
• Horm Teresa

Classifications

• A61K36/605 Primary

  Morus (mulberry) · CPC title

• A61K31/353

  3,4-Dihydrobenzopyrans, e.g. chroman, catechin · CPC title

• A61K31/7008

  Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine · CPC title

• A61K2300/00

  Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00 · CPC title

• A61K31/728

  Hyaluronic acid · CPC title