Compositions and methods for managing or improving bone disorders, joint disorders, cartilage disorders, or a combination thereof

Patent metadata

Field	Value
Publication number	US-10583161-B2
Application number	US-201715808580-A
Country	US
Kind code	B2
Filing date	Nov 9, 2017
Priority date	Jun 16, 2014
Publication date	Mar 10, 2020
Grant date	Mar 10, 2020

Abstract

Compositions and methods for bone health, cartilage health or both, are disclosed that include preparing and utilizing a mixture of at least one Morus extract enriched for one or more prenylated flavonoids, at least one Scutellaria extract enriched for one or more free-B-ring flavonoids, and at least one Acacia extract enriched for one or more flavans.

First claim

We claim:

1. A composition for bone health, cartilage health or both, comprising a mixture of at least one Morus extract enriched for one or more prenylated flavonoids, at least one Scutellaria extract enriched for one or more free-B-ring flavonoids, and at least one Acacia extract enriched for one or more flavans, wherein the Morus extract, the Scutellaria extract, and the Acacia extract are blended in a 1.3:1:1 weight ratio.

2. The composition according to claim 1 , wherein the Morus extract is from Morus alba , the Scutellaria extract is from Scutellaria baicalensis , and the Acacia extract is from Acacia catechu.

3. The composition according to claim 1 , wherein the Acacia extract comprises 0.01% to 99.9% flavans.

4. The composition according to claim 1 , wherein the Morus extract comprises 0.1% to 49.9% prenylated flavonoids.

5. The composition according to claim 1 , wherein the Scutellaria extract comprises 0.01% to 99.9% free-B-ring flavonoids.

6. The composition according to claim 1 , wherein the one or more prenylated flavonoids comprises Kuwanon G.

7. The composition according to claim 1 , wherein the one or more flavans comprises catechin.

8. The composition according to claim 1 , wherein the composition additionally comprises a glucosamine-type compound.

9. The composition according to claim 8 , wherein the glucosamine-type compound comprises glucosamine sulfate.

10. The composition according to claim 1 , wherein the composition further comprises a pharmaceutically or nutraceutically acceptable carrier, diluent, or excipient, wherein the pharmaceutical or nutraceutical formulation comprises from about 0.5 weight percent (wt %) to about 90 wt % of active ingredients of the extract mixture.

11. The composition according to claim 10 , wherein the composition is formulated as a tablet.

12. A composition for bone health, cartilage health or both, comprising a mixture of at least one Moms extract enriched for one or more prenylated flavonoids, at least one Scutellaria extract enriched for one or more free-B-ring flavonoids, and at least one Acacia extract enriched for one or more flavans, wherein the Morus extract, the Scutellaria extract, and the Acacia extract are blended in a 0.410:0.308:0.282 weight ratio.

Assignees

• Unigen Inc

Inventors

• Jia Qi
• Jiao Ping
• Yimam Mesfin
• Horm Teresa

Classifications

• A61K36/48

  Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae · CPC title

• A61K2300/00

  Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00 · CPC title

• A61K31/353

  3,4-Dihydrobenzopyrans, e.g. chroman, catechin · CPC title

• A61K36/605 Primary

  Morus (mulberry) · CPC title

• A61K31/737

  Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate (A61K31/727 takes precedence) · CPC title