Mic reduction with lithium ions

Patent metadata

Field	Value
Publication number	US-11553718-B2
Application number	US-202016923214-A
Country	US
Kind code	B2
Filing date	Jul 8, 2020
Priority date	Apr 10, 2014
Publication date	Jan 17, 2023
Grant date	Jan 17, 2023

Abstract

The invention relates to a process for reducing the minimum inhibitory concentration (MIC) of a biocide against at least one strain of bacteria and/or at least one strain of yeast and/or at least one strain of mould in an aqueous preparation. The invention further relates to the use of a water soluble source of lithium ions for reducing the minimum inhibitory concentration (MIC) of a biocide against at least one strain of bacteria and/or at least one strain of yeast and/or at least one strain of mould in an aqueous preparation.

First claim

The invention claimed is:

1. An aqueous preparation comprising
(i) from 15.0 to 800.0 mMol/L, calculated relative to the weight of water in the aqueous preparation, of lithium ions in the water phase of the aqueous preparation, and
(ii) at least one biocide, wherein said biocide is selected from phenols, halogenated phenols, isothiazolinones, guanidines, sulfones, thiocyanates, pyrithiones, antibiotics β-lactam antibiotics, quaternary ammonium salts, peroxides, perchlorates, amides, amines, heavy metals, biocidal enzymes, biocidal polypeptides, azoles, carbamates, glyphosates, sulphonamides, 2-bromo-2-nitro-1,3-propanediol, 5-bromo-5-nitro-1,3-dioxane, 2,2-dibrom-3-nitrilpropionamid (DBNPA), 1,2-dibromo-2,4-dicyanobutane, monochloroamine, ammonium bromide, calcium hypochlorite, iodine, tri-iodide, potassium iodate, and any mixture thereof; and said biocide being effective against at least one strain of bacteria and/or at least one strain of yeast and/or at least one strain of mould,
wherein the lithium ions are present in a greater than stoichiometric ratio in relation to the biocide,
(iii) at least one inorganic particulate material, and
(iv) optionally at least one organic material selected from carbohydrates, glycerol, hydrocarbons and mixtures thereof; and

wherein the aqueous preparation comprises the at least one biocide in an amount such that the minimum inhibitory concentration (MIC) of the at least one biocide against the at least one strain of bacteria and/or at least one strain of yeast and/or at least one strain of mould fulfils the equation (I)
MIC withoutLi /MIC Li ≥1.1  (I)

wherein
MIC withoutLi is the minimum inhibitory concentration (MIC) of the at least one biocide against the at least one strain of bacteria and/or at least one strain of yeast and/or at least one strain of mould without the water soluble lithium ions in ppm, calculated relative to the weight of water in the aqueous preparation,
MIC Li is the minimum inhibitory concentration (MIC) of the at least one biocide against the at least one strain of bacteria and/or at least one strain of yeast and/or at least one strain of mould with the water soluble lithium ions in ppm, calculated relative to the weight of water in the aqueous preparation;
and wherein the at least one biocide is free of aldehyde-releasing and/or aldehyde-based biocides.

2. The aqueous preparation according to claim 1 , wherein the aqueous preparation comprises the at least one biocide in an amount such that the minimum inhibitory concentration (MIC) of the at least one biocide against the at least one strain of bacteria and/or at least one strain of yeast and/or at least one strain of mould meets equation (Ia), or equation (Ib), or equation (Ic):
MIC withoutLi /MIC Li ≥1.5  (Ia)

MIC withoutLi /MIC Li ≥2.0  (Ib)

MIC withoutLi /MIC Li ≥4.0  (Ic)

wherein
MIC withoutLi is the minimum inhibitory concentration (MIC) of the at least one biocide against the at least one strain of bacteria and/or at least one strain of yeast and/or at least one strain of mould without the water soluble lithium ions in ppm, calculated relative to the weight of water in the aqueous preparation,
MIC Li is the minimum inhibitory concentration (MIC) of the at least one biocide against the at least one strain of bacteria and/or at least one strain of yeast and/or at least one strain of mould with the water soluble lithium ions in ppm, calculated relative to the weight of water in the aqueous preparation.

3. The aqueous preparation according to claim 1 , wherein the aqueous preparation further comprises at least one organic material selected from carbohydrates, glycerol, hydrocarbons and mixtures thereof.

4. The aqueous preparation according to claim 1 , wherein the aqueous preparation has a solids content of up to 85.0 wt.-%, based on the total weight of the aqueous preparation.

5. The aqueous preparation according to claim 1 , wherein the at least one strain of bacteria is selected from the group consisting of gram-negative bacteria, gram-positive bacteria and mixtures thereof.

6. The aqueous preparation according to claim 1 , wherein
(i) the at least one strain of bacteria is selected from the group comprising Methylobacterium sp., Salmonella sp., Escherichia sp. Shigella sp., Enterobacter sp., Pseudomonas sp. Bdellovibrio sp., Agrobacterium sp., Alcaligenes sp., Flavobacterium sp., Rhizobium sp., Sphingobacterium sp., Aeromonas sp., Chromobacterium sp., Vibrio sp., Hyphomicrobium sp., Leptothrix sp., Micrococcus sp., Staphylococcus sp. Agromyces sp., Acidovorax sp., and mixtures thereof, and/or
(ii) the at least one strain of yeast is selected from the group comprising Saccharomycotina, Taphrinomycotina, Schizosaccharomycetes, Basidiomycota, Agaricomycotina, Tremellomycetes, Pucciniomycotina, Microbotryomycetes, Candida sp., Yarrowia sp., Cryptococcus sp., Zygosaccharomyces sp., Rhodotorula sp., and mixtures thereof, and/or
(iii) the at least one strain of mould is selected from the group comprising of Acremonium sp., Alternaria sp., Aspergillus sp., Cladosporium sp., Fusarium sp., Mucor sp., Penicillium sp., Rhizopus sp., Stachybotrys sp., Trichoderma sp., Dematiaceae sp., Phoma sp., Eurotium sp., Scopulariopsis sp., Aureobasidium sp., Monilia sp., Botrytis sp., Stemphylium sp., Chaetomium sp., Mycelia sp., Neurospora sp., Ulocladium sp., Paecilomyces sp., Wallemia sp., Curvularia sp., and mixtures thereof.

7. The aqueous preparation according to claim 1 , wherein the at least one biocide is selected to be:
(i) in an amount of at least 9%, below the minimum inhibitory concentration (MIC) of the at least one biocide for the at least one strain of bacteria and/or at least one strain of yeast and/or at least one strain of mould, and/or
(ii) in an amount of from 0.5 ppm to 6000 ppm, calculated relative to the weight of water in the aqueous preparation.

8. The aqueous preparation according to claim 1 , wherein the at least one biocide is selected to be in an amount of at least 33%, below the minimum inhibitory concentration (MIC) of the at least one biocide for the at least one strain of bacteria and/or at least one strain of yeast and/or at least one strain of mould.

9. The aqueous preparation according to claim 1 , wherein the at least one biocide is selected to be in an amount of at least 50%, below the minimum inhibitory concentration (MIC) of the at least one biocide for the at least one strain of bacteria and/or at least one strain of yeast and/or at least one strain of mould.

10. The aqueous preparation according to claim 1 , wherein the at least one biocide is selected to be in an amount of at least 75%, below the minimum inhibitory concentration (MIC) of the at least one biocide for the at least one strain of bacteria and/or at least one strain of yeast and/or at least one strain of mould.

11. The aqueous preparation according to claim 1 , wherein the at least one inorganic particulate material is selected from natural ground calcium carbonate, natural and/or synthetic precipitated calcium carbonate, dolomite, kaolin, talcum, aluminium hydroxide, aluminium silicate, titanium dioxide and mixtures thereof.

12. The aqueous preparation according to claim 11 ,
wherein the at least one inorganic particulate material comprises natural ground calcium carbonate and/or synthetic precipitated calcium carbonate.

13. The aqueous preparation according to claim 1 , wherein the aqueous preparation has
(i) a pH value of from 6 to 12, and/or
(ii) a solids content of from 10.0 to 82.0 wt.-%

Assignees

• Omya Int Ag

Inventors

• Zumsteg Anita
• Glaubitz Joachim
• Urwyler Simon
• Buri Matthias
• Gane Patrick A C

Classifications

• A01N47/02

  the carbon atom having no bond to a nitrogen atom · CPC title

• A01N43/80

  five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2 · CPC title

• A01N43/78

  1,3-Thiazoles; Hydrogenated 1,3-thiazoles · CPC title

• A01N47/44

  Guanidine; Derivatives thereof · CPC title

• A01N33/20

  containing oxygen or sulfur attached to the carbon skeleton containing the nitro group · CPC title