Mic reduction with lithium ions

Patent metadata

Field	Value
Publication number	US-10743541-B2
Application number	US-201515125706-A
Country	US
Kind code	B2
Filing date	Apr 8, 2015
Priority date	Apr 10, 2014
Publication date	Aug 18, 2020
Grant date	Aug 18, 2020

Abstract

The invention relates to a process for reducing the minimum inhibitory concentration (MIC) of a biocide against at least one strain of bacteria and/or at least one strain of yeast and/or at least one strain of mould in an aqueous preparation. The invention further relates to the use of a water soluble source of lithium ions for reducing the minimum inhibitory concentration (MIC) of a biocide against at least one strain of bacteria and/or at least one strain of yeast and/or at least one strain of mould in an aqueous preparation.

First claim

The invention claimed is:

1. A process for reducing the minimum inhibitory concentration (MIC) of a biocide against at least one strain of bacteria and/or at least one strain of yeast and/or at least one strain of mould in an aqueous preparation, the process comprising the steps of:
a) providing an aqueous preparation,
b) providing at least one biocide selected from the group consisting of phenols, halogenated phenols, halogen-containing compounds, halogen-releasing compounds, isothiazolinones, guanidines, sulfones, thiocyanates, pyrithiones, antibiotics, β-lactam antibiotics, quaternary ammonium salts, peroxides, perchlorates, amides, amines, heavy metals, biocidal enzymes, biocidal polypeptides, azoles, carbamates, glyphosates, sulphonamides, and any mixture thereof,
c) providing at least one water soluble source of lithium ions,
d) contacting the aqueous preparation of step a) with the at least one biocide of step b), wherein the at least one biocide is effective against at least one strain of bacteria and/or at least one strain of yeast and/or at least one strain of mould when present in the aqueous preparation,
e) contacting the aqueous preparation of step a) before and/or during and/or after step d) with the at least one water soluble source of lithium ions of step c),
wherein the amount of the lithium ions and the amount of the at least one biocide are selected so that the minimum inhibitory concentration (MIC) of the biocide meets meet equation (I):
MIC withoutLi /MIC Li >1.1  (I)

wherein
MIC withoutLi is the minimum inhibitory concentration (MIC) of the at least one biocide against the at least one strain of bacteria and/or at least one strain of yeast and/or at least one strain of mould without the at least one water soluble source of lithium ions in ppm, calculated relative to the weight of water in the aqueous preparation of step a),
MIC Li , is the minimum inhibitory concentration (MIC) of the at least one biocide against the at least one strain of bacteria and/or at least one strain of yeast and/or at least one strain of mould with the at least one water soluble source of lithium ions in ppm, calculated relative to the weight of water in the aqueous preparation of step a),
wherein the total amount of lithium ions is selected from 15.0 to 800.0 mMol/L, calculated relative to the weight of water in the aqueous preparation, and
wherein the amount of the at least one biocide is selected from 0.4 to 6500.0 ppm, calculated relative to the weight of water in the aqueous preparation; and
wherein the at least one biocide is free of aldehyde-releasing and/or aldehyde-based biocides.

2. The process according to claim 1 , wherein the aqueous preparation of step a) comprises:
(i) at least one inorganic particulate material, and/or
(ii) at least one organic material.

3. The process according to claim 2 , wherein the at least one inorganic particulate material is selected from the group consisting of natural ground calcium carbonate, natural and/or synthetic precipitated calcium carbonate, dolomite, kaolin, talcum, aluminium hydroxide, aluminium silicate, titanium dioxide, and any mixture thereof, and the at least one organic material is selected from the group consisting of carbohydrates, starch, sugar, cellulose and cellulose based pulp, glycerol, hydrocarbons, and any mixture thereof.

4. The process according to claim 2 , wherein the at least one inorganic particulate material is natural ground calcium carbonate and/or synthetic precipitated calcium carbonate.

5. The process according to claim 1 , wherein the aqueous preparation of step a) and/or of step d) and/or of step e) has:
(i) a pH value of from 2 to 12, and/or
(ii) a solids content of up to 85.0 wt.-%, based on the total weight of the aqueous preparation.

6. The process according to claim 1 , wherein the aqueous preparation of step a) and/or of step d) and/or of step e) has:
(i) a pH value of from 6 to 12, and/or
(ii) a solids content of from 10.0 to 82.0 wt.-%, based on the total weight of the aqueous preparation.

7. The process according to claim 1 , wherein the aqueous preparation of step a) and/or of step d) and/or of step e) has:
(i) a pH value of from 7 to 10.5, and/or
(ii) a solids content of from 20.0 to 80.0 wt.-%, based on the total weight of the aqueous preparation.

8. The process according to claim 1 , wherein the at least one strain of bacteria is selected from the group consisting of gram-negative bacteria, gram-positive bacteria, and any mixture thereof.

9. The process according to claim 1 , wherein:
(i) the at least one strain of bacteria is selected from the group consisting of Methylobacterium sp., Salmonella sp., Escherichia sp., Escherichia coli, Shigella sp., Enterobacter sp., Pseudomonas sp., Pseudomonas mendocina, Bdellovibrio sp., Agrobacterium sp., Alcaligenes sp., Flavobacterium sp., Rhizobium sp., Sphingobacterium sp., Aeromonas sp., Chromobacterium sp., Vibrio sp., Hyphomicrobium sp., Leptothrix sp., Micrococcus sp., Staphylococcus sp., Staphylococcus aureus, Agromyces sp., Acidovorax sp., and any mixture thereof, and/or
(ii) the at least one strain of yeast is selected from the group consisting of Saccharomycotina, Taphrinomycotina, Schizosaccharomycetes, Basidiomycota, Agaricomycotina, Tr emellomycetes , Pucciniomycotina, Microbotryomycetes, Candida sp., Candida albicans, Candida tropicalis, Candida stellatoidea, Candida glabrata, Candida krusei, Candida guilliermondii, Candida viswanathii, Candida lusitaniae, Yarrowia sp., Yarrowia lipolytica, Cryptococcus sp., Crypt ococcus gattii, Cryptococcus neofarmans, Zygosaccharomyces sp., Rhodotorula sp., Rhodotorula mucilaginosa , and any mixture thereof, and/or
(iii) the at least one strain of mould is selected from the group consisting of Acremonium sp., Alternaria sp., Aspergillus sp., Cladosporium sp., Fusarium sp., Mucor sp., Penicillium sp., Rhizopus sp., Stachybotrys sp., Trichoderma sp., Dematiaceae sp., Phoma sp., Eurotium sp., Scopulariopsis sp., Aureobasidium sp., Monilia sp., Botrytis sp., Stemphylium sp., Chaetomium sp., Mycelia sp., Neurospora sp., Ulocladium sp., Paecilomyces sp., Wallemia sp., Curvularia sp., and any mixture thereof.

10. The process according to claim 1 , wherein the at least one water soluble source of lithium ions is at least one lithium salt.

11. The process according to claim 1 , wherein the at least one water soluble source of lithium ions is at least one lithium salt selected from the group consisting of lithium carbonate, lithium chloride, lithium hydroxide, lithium phosphate, lithium citrate, lithium maleate, lithium acetate and lithium lactate, polymeric salts of lithium, and any mixture thereof.

12. The process according to claim 1 , wherein the at least one water soluble source of lithium ions is a polymeric salt of lithium selected from the group consisting of lithium salts of acrylic homopolymers, acrylic copolymers, copolymers of acrylic acid and maleic acid and/or acrylamide, polyphosphates, and any mixture thereof.

13. The process according to claim 1 , wherein the at least one water soluble source of lithium ions is a polymeric salt of lithium selected from the group consisting of Li 2 Na 2 polyphosphate, lithium-sodium hexamethaphosphate, lithium polyacrylate.

14. The process according to claim 1 , wherein the at least one biocide is selected to be:
(i) in an amount of at least 9%, below the minimum inhibitory concentration (MIC) of the at least one biocide for the at least one strain of bacteria and/or at least one str

Assignees

• Omya Int Ag

Inventors

• Zumsteg Anita
• Glaubitz Joachim
• Urwyler Simon
• Buri Matthias
• Gane Patrick A C

Classifications

• Y02A50/30

  Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change · CPC title

• A01N35/02

  containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals · CPC title

• A01N59/00 Primary

  Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds · CPC title

• A01N43/40

  six-membered rings · CPC title

• A01N43/32

  six-membered rings · CPC title