Method for producing 225Ac

Patent metadata

Field	Value
Publication number	US-11551826-B2
Application number	US-202217846398-A
Country	US
Kind code	B2
Filing date	Jun 22, 2022
Priority date	Jul 2, 2019
Publication date	Jan 10, 2023
Grant date	Jan 10, 2023

Abstract

A method for producing 225 A including: a method (X) for purifying a 226 Ra-containing solution, including an adsorption step of allowing a 226 Ra ion to adsorb onto a carrier having a function of selectively adsorbing a divalent cation by bringing a 226 Ra-containing solution into contact with the carrier under an alkaline condition, and an elution step of eluting the 226 Ra ion from the carrier under an acidic condition; a method for producing a 226 Ra target, including an electrodeposition liquid preparation step of preparing an electrodeposition liquid by using a purified 226 Ra-containing solution obtained by the method (X), and an electrodeposition step of electrodepositing a 226 Ra-containing substance on a substrate by using the electrodeposition liquid; and a step of irradiating a 226 Ra target produced by the method for producing a 226 Ra target with at least one selected from a charged particle, a photon, and a neutron by using an accelerator.

First claim

The invention claimed is:

1. A method for producing 225 Ac, comprising:
a method (X) for purifying a 226 Ra-containing solution, comprising an adsorption step (R 1 ) of allowing a 226 Ra ion to adsorb onto a resin carrier having a function of selectively adsorbing a divalent cation by bringing a 226Ra-containing solution (a) into contact with the carrier under an alkaline condition, and an elution step (R 2 ) of eluting the 226 Ra ion from the carrier under an acidic condition;
a method for producing a 226 Ra target, comprising an electrodeposition liquid preparation step (R 4 ) of preparing an electrodeposition liquid by using a purified 226 Ra-containing solution (b) obtained by the method (X), and an electrodeposition step (R 5 ) of electrodepositing a 226 Ra-containing substance on a substrate by using the electrodeposition liquid; and
a step (A 1 ) of irradiating a 226 Ra target produced by the method for producing a 226 Ra target with at least one kind selected from a charged particle, a photon, and a neutron by using an accelerator to produce 225 Ac.

2. The method for producing 225 Ac according to claim 1 , wherein
the carrier has a divalent cation-exchange group.

3. The method for producing 225 Ac according to claim 1 , wherein
the carrier has an iminodiacetic acid group.

4. The method for producing 225 Ac according to claim 1 , the method (X) further comprises a step (R 3 ) of performing anion exchange by passing a solution containing a 226 Ra ion eluted in the elution step (R 2 ) through an anion exchange resin.

5. The method for producing 225 Ac according to claim 1 , wherein
the 226 Ra-containing solution (a) is obtained by separating an 225 Ac component from a solution in which a 226 Ra target irradiated with at least one kind selected from a charged particle, a photon, and a neutron by using an accelerator has been dissolved.

6. The method for producing 225 Ac according to claim 1 , wherein
the carrier is charged in a tube.

7. The method for producing 225 Ac according to claim 1 , further comprising
a purification method (Y) comprising the steps:
(R 6 ) of allowing a 226 Ra ion to adsorb onto a carrier having a function of selectively adsorbing a divalent cation by bringing a 226 Ra-containing solution (c) after the electrodeposition step (R 5 ) into contact with the carrier under an alkaline condition; and
(R 7 ) of eluting the 226 Ra ion from the carrier under an acidic condition, wherein
a purified 226 Ra-containing solution (d) obtained by the purification method (Y) is mixed with the purified 226 Ra-containing solution (b), and an electrodeposition liquid is prepared in the electrodeposition liquid preparation step (R 4 ).

8. The method for producing 225 Ac according to claim 7 , the purification method (Y) further comprises a step
(R 8 ) of performing anion exchange by passing a solution containing a 226 Ra ion eluted in the elution step (R 7 ) through an anion exchange resin.

9. The method for producing 225 Ac according to claim 1 , further comprising the steps:
(A 2 ) of dissolving the 226 Ra target irradiated in the irradiation step (A 1 ); and
(A 3 ) of separating a colloidal 225 Ac component by alkalizing the solution obtained in the dissolution step (A 2 ).

Assignees

• Nihon Mediphysics Co Ltd

Inventors

• Honda Yoshio
• Yano Shinya

Classifications

• G21G1/06

  by neutron irradiation · CPC title

• B01D59/50 Primary

  Separation involving two or more processes covered by different groups selected from groups B01D59/02, B01D59/10, B01D59/20, B01D59/22, B01D59/28, B01D59/34, B01D59/36, B01D59/38, B01D59/44 · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• B01D15/363

  Anion-exchange · CPC title

• G21G2001/0094

  Other isotopes not provided for in the groups listed above · CPC title