Molecularly imprinted polymers for removal of trimethylamine N-oxide

Patent metadata

Field	Value
Publication number	US-11524275-B2
Application number	US-202016837828-A
Country	US
Kind code	B2
Filing date	Apr 1, 2020
Priority date	Apr 2, 2019
Publication date	Dec 13, 2022
Grant date	Dec 13, 2022

Abstract

The present disclosure features a composition, including molecularly imprinted crosslinked polymers that have been imprinted with trimethylamine N-oxide. The molecularly imprinted crosslinked polymers have specific binding sites for trimethylamine N-oxide, and a trimethylamine N-oxide absorption capacity of at least 0.5 mg/g.

First claim

The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows:

1. A method of removing trimethylamine N-oxide from a hemodialysis dialysate, comprising:
passing the hemodialysis dialysate comprising trimethylamine N-oxide through a crosslinked polymer derived from:
a monomer comprising a (C 0-6 alkyl)acrylic acid, di(C 1-6 alkyl)acrylic acid, or any combination thereof, and
a crosslinker comprising a (C 1-6 alkylene glycol)-di(C 1-6 alkyl)acrylate, trimethylolpropane trimethacrylate, N,N′-methylenebisacrylamide, or any combination thereof,
wherein the crosslinked polymer comprises specific binding sites for trimethylamine N-oxide and a trimethylamine N-oxide absorption capacity of at least 0.5 mg/g; and

absorbing the trimethylamine N-oxide onto the crosslinked polymer to remove the trimethylamine N-oxide from the hemodialysis dialysate.

2. The method of claim 1 , further comprising washing the crosslinked polymer to remove the absorbed trimethylamine N-oxide from the crosslinked polymer.

3. The method of claim 1 , wherein the crosslinked polymer is in the form of a plurality of particles, the plurality of particles further contained in a chromatography column or a chromatography cartridge.

4. The method of claim 3 , wherein the hemodialysis dialysate is passed through the chromatography column or a chromatography cartridge at a rate of 1 ml/minute or more.

5. The method of claim 1 , further comprising passing the hemodialysis dialysate through a filter to remove urea present in the hemodialysis dialysate prior to, concurrent with, or subsequent to passing the hemodialysis dialysate through the crosslinked polymer.

6. The method of claim 1 , further comprising passing the hemodialysis dialysate through a filter to remove albumin-bound toxins present in the hemodialysis dialysate prior to, concurrent with, or subsequent to passing the hemodialysis dialysate through the crosslinked polymer.

Assignees

• Univ Washington

Inventors

• Ratner Buddy D
• Tang Runbang

Classifications

• B01D15/3852

  using imprinted phases or molecular recognition · CPC title

• B01J20/267

  Cross-linked polymers · CPC title

• B01J20/28004

  Sorbent size or size distribution, e.g. particle size · CPC title

• B01J2220/58

  Use in a single column · CPC title

• B01J20/268 Primary

  Polymers created by use of a template, e.g. molecularly imprinted polymers · CPC title