Body contour adaptable autoinjector device

Patent metadata

Field	Value
Publication number	US-11511051-B2
Application number	US-202016842468-A
Country	US
Kind code	B2
Filing date	Apr 7, 2020
Priority date	Mar 15, 2013
Publication date	Nov 29, 2022
Grant date	Nov 29, 2022

Abstract

An injector for delivering a therapeutic product may include a base having a flexible surface that conforms to various body contours of a patient and defines one or more an injection chambers. The injector may have a height that is substantially less than its width, thereby defining a low profile, which provides a larger more stable base that can pinch or stretch the skin in a controlled manner. The larger base can also accommodate larger volumes via multiple injection chambers and/or large combined primary containers.

First claim

What it claimed is:

1. An injector for delivering a therapeutic product, the injector comprising:
a base having a bottom surface;
a flexible layer coupled to the bottom surface of the base that conforms to various body contours of a patient;
an injection chamber, wherein the flexible layer forms a vacuum with the skin of the patient to draw the skin of the patient into the injection chamber;
a cover disposed over the base; and
an air vent arrangement including a vent aperture and a closure for opening and closing the vent aperture, wherein movement of the cover relative to the base in a first direction causes air to move through the vent aperture from a first side of the closure to a second side of the closure, which is opposite the first side, the air vent arrangement being configured to:
(i) close the vent aperture with the closure when the cover is moved relative to the base in the first direction after air is displaced therethrough, and
(ii) subsequently open the vent aperture to release the vacuum when the cover is moved relative to the base in a second direction, which is opposite the first direction.

2. The injector of claim 1 , wherein the air vent arrangement comprises the vent aperture extending through the base.

3. The injector of claim 1 , further comprising a support post, the support post configured to receive air therein when the air vent arrangement is open.

4. The injector of claim 1 , further comprising one or more springs disposed between the base and cover, the one or more springs configured to bias the base and cover away from one another.

5. The injector of claim 4 , wherein movement of the cover and the base towards one another from a first position to a second position causes air to move through the air vent arrangement; and the one or more springs are configured to return the cover and base to the first position to thereby release the vacuum.

6. The injector of claim 4 , further comprising return posts having telescoping components, such that the return posts are collapsible when the cover and the base are moved towards one another.

7. The injector of claim 1 , further comprising an isolator disposed over the injection chamber.

8. The injector of claim 1 , further comprising:
a container or syringe disposed within the injector, the container or syringe containing a therapeutic product and comprising a needle for injecting the therapeutic product into the patient;
a needle shield removably attached to the container or syringe over at least a distal end of the needle; and
a peelable substrate disposed over the flexible layer for removing the needle shield from the container or syringe.

9. The injector of claim 8 , wherein the peelable substrate comprises:
a structure which can be folded into a pull-tab to facilitate removal of the peelable substrate from the surface of the base or;
a structure with opposing portions that can be folded down against one another to facilitate removal of the peelable substrate from the surface of the base; or
a projection extending from an attachment surface thereof for attaching the peelable substrate to the needle shield.

10. The injector of claim 8 , wherein the cover has a window for viewing the container or syringe during an injection cycle of the injector.

11. The injector of claim 8 , further comprising a carrier provided on the base, the carrier for moving the container or syringe between first and second positions during an injection cycle, the needle disposed within the injector in the first position, the needle extending from the base in the second position.

12. The injector of claim 11 , wherein the container or syringe further comprises a plunger for dispensing the therapeutic product from the container or syringe and through the needle; and further comprising a plunger drive for driving the plunger through the container or syringe to dispense the therapeutic product from the container or syringe and through the needle, wherein the plunger drive is activated by pressing the cover toward the base.

13. The injector of claim 11 , further comprising a carrier drive for moving the carrier between the first and second positions, wherein the carrier drive is activated by pressing the cover toward the base.

14. The injector of claim 13 , wherein the carrier drive is disposed at an acute angle relative to the base.

15. The injector of claim 14 , further comprising a needle guide for bending the needle into the injection chamber.

16. The injector of claim 11 , further comprising a heating element disposed adjacent to the carrier for heating the therapeutic product contained in the container or syringe.

17. The injector of claim 11 , wherein the container or syringe comprises at least two barrels coupled to the needle, each barrel containing a therapeutic product.

18. The injector of claim 11 , further comprising at least a second carrier.

19. The injector of claim 18 , further comprising a second container or syringe, the second carrier for moving the second container or syringe between the first and second positions.

20. The injector of claim 1 , wherein the cover comprises at least one of a palm-button for pressing the cover toward the base to start an injection cycle of the injector, at least one finger-pad for gripping the injector, or a layer of material for hand or finger gripping of the injector.

Assignees

• Amgen Inc

Inventors

• Lee Mark Ka Lai
• Toy Stephanie
• Fenster Valerie M

Classifications

• A61M5/445

  the media being heated in the reservoir, e.g. warming bloodbags · CPC title

• A61M5/20

  Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically (A61M5/142 {, A61M5/46} take precedence; {hypodermic projectiles F42B12/54}) · CPC title

• A61M5/425

  Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means · CPC title

• A61M2005/3022

  Worn on the body, e.g. as patches (pressure infusion of the skin patch type A61M5/14248) · CPC title

• A61M5/31576

  Constructional features or modes of drive mechanisms for piston rods · CPC title