Body contour adaptable autoinjector device

Patent metadata

Field	Value
Publication number	US-10646664-B2
Application number	US-201414776693-A
Country	US
Kind code	B2
Filing date	Mar 14, 2014
Priority date	Mar 15, 2013
Publication date	May 12, 2020
Grant date	May 12, 2020

Abstract

An injector for delivering a therapeutic product may include a base having a flexible surface that conforms to various body contours of a patient and defines one or more an injection chambers. The injector may have a height that is substantially less than its width, thereby defining a low profile, which provides a larger more stable base that can pinch or stretch the skin in a controlled manner. The larger base can also accommodate larger volumes via multiple injection chambers and/or large combined primary containers.

First claim

What is claimed is:

1. An injector for delivering a therapeutic product comprising:
a base having a bottom surface;
a flexible layer coupled to the bottom surface of the base that conforms to various body contours of a patient;
an injection chamber, wherein the flexible layer forms a vacuum with the skin of the patient and the vacuum draws the skin of the patient into the injection chamber;
a cover disposed over the base;
a vent aperture, wherein the cover is movable relative to the base from a first position to a second position to cause air to move through the vent aperture for releasing the vacuum generated between the flexible layer and the skin, the cover and base being coupled together in both the first position and the second position; and
a flexible isolator disposed over the injection chamber, the isolator having a concave surface for drawing a portion of the skin up into the injection chamber.

2. The injector of claim 1 , further comprising:
a container or syringe disposed within the injector, the container or syringe containing a therapeutic product;
a needle shield removably attached to the container or syringe; and
a peelable substrate disposed over the flexible layer for removing the needle shield from the container or syringe.

3. The injector of claim 2 , wherein the peelable substrate comprises:
a structure which can be folded into a pull-tab to facilitate removal of the peelable substrate from the flexible layer; or
a structure with opposing portions that can be folded down against one another to facilitate removal of the peelable substrate from the flexible layer; or
a projection extending from an attachment surface thereof for attaching the peelable substrate to the needle shield.

4. The injector of claim 2 , wherein the cover has a window for viewing the container or syringe during an injection cycle of the injector.

5. The injector of claim 2 , wherein the container or syringe has a needle for injecting the therapeutic product contained within the container or syringe into the patient and further comprising a carrier provided on the base, the carrier for moving the container or syringe between a first position and a second position during an injection cycle of the injector, the needle disposed within the injector in the first position, the needle extending from the base in the second position.

6. The injector of claim 5 , wherein the container or syringe has a plunger for dispensing the therapeutic product from the container or syringe and through the needle and further comprising a plunger drive for driving the plunger through the container or syringe to dispense the therapeutic product from the container or syringe and through the needle, the plunger drive comprising a spring, a hydraulic actuator, or any combination thereof, wherein the plunger drive is activated by pressing the cover toward the base.

7. The injector of claim 5 , further comprising a carrier drive for moving the carrier between the first position and the second position, the carrier drive having a spring drive element, a hydraulic drive element, or any combination thereof, wherein the carrier drive is activated by pressing the cover toward the base.

8. The injector of claim 7 , wherein the carrier drive is disposed at an acute angle relative to the base.

9. The injector of claim 8 , further comprising a needle guide for bending the needle into the injection chamber.

10. The injector of claim 5 , further comprising a heating element disposed adjacent to the carrier for heating the therapeutic product contained in the container or syringe.

11. The injector of claim 10 , wherein the heating element comprises an exothermic heating element.

12. The injector of claim 5 , wherein the container or syringe has a plunger for dispensing the therapeutic product from the container or syringe and through the needle and further comprising a plunger drive for driving the plunger through the container or syringe to dispense the therapeutic product from the container or syringe and through the needle and a carrier drive for moving the carrier between the first and second positions, each of the plunger and carrier drives having, a spring drive element, a hydraulic drive element, or any combination thereof, wherein at least one of the plunger and carrier drives is activated by pressing the cover toward the base.

13. The injector of claim 5 , wherein the container or syringe comprises at least two barrels coupled to the needle, each barrel containing a therapeutic product.

14. The injector of claim 5 , further comprising at least a second carrier.

15. The injector of claim 14 , further comprising at least a second container or syringe, the second carrier for moving the second container or syringe between the first position and the second position.

16. The injector of claim 1 , wherein the cover comprises at least one of: a palm-button for pressing the cover toward the base to start an injection cycle of the injector, at least one finger-pad for gripping the injector, or a layer of material for hand or finger gripping of the injector.

17. The injector of claim 16 , wherein the at least one finger-pad is located on the cover to meet a gripping requirement of a certain patient population.

18. The injector of claim 1 , wherein the injector has a low profile with a height less than a width.

19. The injector of claim 1 , wherein the flexible layer is further for stretching or pinching the skin.

20. An injector for delivering a therapeutic product comprising:
a base having a bottom surface;
a flexible layer coupled to the bottom surface of the base that conforms to various body contours of a patient;
an injection chamber, wherein the flexible layer forms a vacuum with the skin of the patient and the vacuum draws the skin of the patient into the injection chamber;
a cover disposed over the base;
a vent aperture, wherein the cover is movable relative to the base from a first position to a second position to cause air to move through the vent aperture for releasing the vacuum generated between the flexible layer and the skin, the cover and base being coupled together in both the first position and the second position;
a container or syringe disposed within the injector, the container or syringe containing a therapeutic product;
a needle shield removably attached to the container or syringe; and
a peelable substrate disposed over the flexible layer for removing the needle shield from the container or syringe.

Assignees

• Amgen Inc

Inventors

• Lee Mark Ka Lai
• Toy Stephanie
• Fenster Valerie M

Classifications

• A61M5/425

  Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means · CPC title

• A61M2005/3022

  Worn on the body, e.g. as patches (pressure infusion of the skin patch type A61M5/14248) · CPC title

• A61M5/20

  Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically (A61M5/142 {, A61M5/46} take precedence; {hypodermic projectiles F42B12/54}) · CPC title

• A61M5/31576

  Constructional features or modes of drive mechanisms for piston rods · CPC title

• A61M5/19 Primary

  having more than one chamber {, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly (surgical glue applicators A61B17/00491)} · CPC title