Ligament reconstruction

Patent metadata

Field	Value
Publication number	US-11511017-B2
Application number	US-202016815228-A
Country	US
Kind code	B2
Filing date	Mar 11, 2020
Priority date	Mar 12, 2019
Publication date	Nov 29, 2022
Grant date	Nov 29, 2022

Abstract

The present disclosure describes methods of treating a ligament injury with ligament grafting.

First claim

What is claimed is:

1. A method of anterior cruciate ligament repair comprising:
a) wrapping amnion tissue around a tissue graft to form a wrapped graft;
b) placing at least one cerclage stitch at either end of the amnion tissue and one running stitch at the end of the wrapped graft to form a water-tight compartment;
c) inserting the wrapped graft into a knee joint; and
d) adding i) a ligament composition ii) platelet rich plasma (PRP), bone marrow concentrate (BMC), or a combination of PRP and BMC, and iii) thrombin or an animal source activating agent to cause gelation to the water-tight compartment between the amnion tissue and the tissue graft.

2. The method of claim 1 , wherein the amnion is wrapped more than once around the tissue graft.

3. The method of claim 1 , wherein the ligament composition and the PRP, BMC, or a combination of PRP and BMC are added to the water-tight compartment as one mixture.

4. The method of claim 1 , wherein the ligament composition and the PRP, BMC, or a combination of PRP and BMC are added to the water-tight compartment separately.

5. A method of ligament repair comprising:
a) wrapping placental tissue around a tissue graft to form a wrapped graft;
b) placing at least one stitch at either end of the placental tissue and one stitch at the end of the wrapped graft to form at least one water-tight compartment; and
c) adding i) a tissue composition ii) a biological agent and iii) thrombin or an animal source activating agent to cause gelation to the at least one water-tight compartment.

6. The method of claim 5 , wherein the at least one water-tight compartment is between the placental tissue and the tissue graft.

7. The method of claim 5 , wherein the biological agent is platelet rich plasma, bone marrow concentrate, viscous amnion, a growth factor, or stem cells.

8. The method of claim 5 , wherein the placental tissue is wrapped around the tissue graft more than once.

9. The method of claim 8 , wherein the biological agent is added to a compartment between different layers of the placental tissue.

10. The method of claim 5 , wherein the placental tissue is amnion, chorion, or umbilical cord.

11. The method of claim 5 , wherein the placental tissue is a placental tissue streamer, an engineered scaffold placental tissue hybrid, or a suture placental tissue hybrid.

12. The method of claim 5 , further comprising inserting the wrapped graft into a knee joint before adding the biological agent to the at least one water-tight compartment.

13. The method of claim 5 , further comprising inserting the wrapped graft into a knee joint after adding the biological agent to the at least one water-tight compartment.

14. The method of claim 5 , wherein the stitch at the end of the wrapped graft is a running stitch.

15. The method of claim 5 , wherein the stitches at either end of the placental tissue are cerclage stitches.

16. The method of claim 5 , wherein the tissue graft is a tissue hybrid.

17. The method of claim 5 , where in the tissue graft is a patellar tendon, a hamstring graft, or a quadriceps tendon graft.

18. The method of claim 5 , wherein the tissue composition and the biological agent are added to the water-tight compartment as one mixture.

19. The method of claim 5 , the tissue composition and the biological agent are added to the water-tight compartment separately.

20. The method of claim 5 , wherein the tissue composition is particulated, minced, digested, or chopped tissue.

Assignees

• Arthrex Inc

Inventors

• Shepard David O
• Harrison Robert
• Benedict Robert

Classifications

• A61L2400/18

  Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment · CPC title

• A61L27/3662 Primary

  Ligaments, tendons · CPC title

• A61L2430/10

  for reconstruction of tendons or ligaments · CPC title

• A61L27/3616

  Blood, e.g. platelet-rich plasma · CPC title

• A61L27/3608 Primary

  Bone, e.g. demineralised bone matrix [DBM], bone powder · CPC title