Collagen and micronized placental tissue compositions and methods of making and using the same

Patent metadata

Field	Value
Publication number	US-2016263281-A1
Application number	US-201615040936-A
Country	US
Kind code	A1
Filing date	Feb 10, 2016
Priority date	Feb 11, 2015
Publication date	Sep 15, 2016
Grant date	—

Abstract

Described herein are compositions of collagen and micronized placental tissue components, methods for producing the same and methods for using the same for wound healing, repairing damaged tendons, cosmetic applications and covering biocompatible materials and/or devices.

First claim

What is claimed is:

1 . A composition comprising water, soluble collagen and micronized placental tissue components such that the composition is an integrated admixture having apparent homogeneity.

2 . The composition of claim 1 which is a coherent and flexible mass.

3 . The composition of claim 1 , wherein the micronized placental tissue components comprise micronized amnion, micronized chorion, micronized Wharton's jelly, or any combination thereof.

4 . The composition of claim 1 , wherein the micronized placental tissue components have a particle size less than 400 μm.

5 . The composition of claim 1 , wherein the micronized placental tissue components comprise a micronized tissue graft comprising an amnion layer and a chorion layer, wherein the chorion layer is layered directly over the amnion layer, and further wherein the amnion layer has an exposed basement membrane and an intact fibroblast component.

6 . The composition of claim 1 , wherein the micronized placental tissue components comprise a micronized tissue graft comprising an amnion layer and a chorion layer, wherein the chorion layer is layered directly over the amnion layer, and further wherein the amnion layer has an intact epithelial cell layer and an intact fibroblast component.

7 . The composition of claim 1 , wherein the collagen is human collagen.

8 . The method of claim 1 , wherein the collagen is an aqueous collagen material comprising from about 0.1% to about 2% collagen.

9 . The composition of claim 1 , wherein the weight ratio of the micronized placental tissue components to the collagen is from about 3:1 to about 100:1.

10 . The composition of claim 1 , wherein the weight ratio of micronized placental tissue components to collagen is about 100:1 to about 300:1.

11 . The composition of claim 10 , wherein the composition is coherent and flexible under physiological conditions.

12 . The composition of claim 1 , wherein the composition is obtained by ejecting a precursor composition comprising aqueous/gelatinous collagen and micronized placental tissue components.

13 . A method for transforming an aqueous/gelatinous collagen mass into a coherent and flexible composition said method comprising:
a. incorporating sufficient micronized placental tissue components into an aqueous collagen material; and b. applying sufficient force and shear to the composition so as to transform the compositions into a coherent, flexible mass.

14 . The method of claim 13 , wherein the aqueous collagen material comprises from about 0.1% to about 2% collagen.

15 . The method of claim 13 , wherein the micronized placental tissue components comprise micronized amnion, micronized chorion, micronized Wharton's jelly, or any combination thereof.

16 . The method of claim 13 , wherein the placental tissue components have a particle size less than 400 μm.

17 . The method of claim 13 , wherein the collagen is human collagen.

18 . The method of claim 13 , wherein the weight ratio of the micronized placental tissue components to the collagen is from about 100:1 to about 300:1.

19 . A method for treating a wound in a subject in need thereof comprising administering to the wound an effective amount of the composition of claim 1 .

20 . A method for treating a cosmetic defect in a subject in need thereof comprising administering to the wound an effective amount of the composition of claim 1 .

Assignees

• Mimedx Group Inc

Inventors

• Koob Thomas J
• Massee Michelle

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P19/04

  for non-specific disorders of the connective tissue · CPC title

• A61P17/02

  for treating wounds, ulcers, burns, scars, keloids, or the like · CPC title

• A61L26/0057

  Ingredients of undetermined constitution or reaction products thereof · CPC title

• A61L26/0033

  Collagen · CPC title