Polymer materials

Patent metadata

Field	Value
Publication number	US-11504033-B2
Application number	US-201716070257-A
Country	US
Kind code	B2
Filing date	Jan 13, 2017
Priority date	Jan 14, 2016
Publication date	Nov 22, 2022
Grant date	Nov 22, 2022

Abstract

Polyurethane material for indicating pH at a locus, preferably as indication of presence of microbes, comprising a polyurethane network having immobilised therein one or more hydrophilic copolymers, the or each said copolymer comprising:hydrophilic monomer; andindicating monomer, which provides an indication in response to a change in hydrophilic state of said hydrophilic monomer and/or copolymer;characterised in that the or each copolymer further comprises one or a plurality of ionisable groups or moieties or polymerisable monomers having one or more characteristic pKa values in the range 5 to 10 and which are responsive to pH at the locus in the range pH 5 to pH 10and in that hydrophilic state of hydrophilic copolymer is dependent on ionisation of said ionisable groups, moieties or monomers; kit and device comprising the material and process for preparation thereof; and use in detecting or sensing microbes or pH.

First claim

The invention claimed is:

1. A polyurethane material for indicating pH at a locus in the range pH 5 to pH 10, the material comprising a polyurethane network having immobilised therein a hydrophilic copolymer, comprising:
a hydrophilic monomer comprising an acryloyl group; and
an ionisable group or moiety provided on the hydrophilic copolymer, the ionisable group or moiety having a characteristic pKa value in the range 2 to 12;
wherein a hydrophilic state of the hydrophilic copolymer is affected by ionisation of the ionisable group or moiety; and
wherein the hydrophilic copolymer further comprises an indicator monomer which provides an indication of the hydrophilic state of the hydrophilic copolymer, the hydrophilic state responsive to changes in pH.

2. The polyurethane material of claim 1 wherein the locus comprises a wound.

3. The polyurethane material of claim 1 , wherein the indicating monomer is a solvatochromic dye or a colour changing indicator.

4. The polyurethane material of claim 1 , wherein the material is configured for medical, dental, hygiene, point of use sterilisation, sanitation, personal care, bio surveillance or packaging use.

5. A kit comprising the polyurethane material of claim 1 , the kit further comprising a reference strip providing reference information for processing information relating to indication and change in indication and generating indicating information and/or a device for reading the indication of the material.

6. A device comprising a wound dressing comprising the polyurethane material of claim 1 , wherein the device is configured for interrogation of wound fluid, a medical or dental sponge or wipe, or pH sensor.

7. A process for the preparation of the polyurethane material of claim 1 , wherein the polyurethane network formation or part thereof is conducted in the presence of the hydrophilic copolymer.

8. The process of claim 7 , wherein said hydrophilic copolymer is present together with an amount of network forming agent, together with polyurethane prepolymers comprising isocyanate terminated monomer and long chain diol and/or polyol or a prepolymer reaction product thereof.

9. The process of claim 7 , wherein the polyurethane network formation comprises cross linking or chain extension.

10. The hydrophilic copolymer of claim 1 , wherein the hydrophilic copolymer is a moderately branched polymer, a highly branched polymer, a hyper branched polymer, or combinations thereof.

11. The hydrophilic copolymer of claim 1 , wherein the hydrophilic copolymer is hyper branched.

12. The hydrophilic copolymer of claim 1 , wherein the hydrophilic monomer is selected from the group consisting of an acrylamide, an acrylate, and an acrylic acid.

13. The hydrophilic copolymer of claim 1 , wherein the hydrophilic copolymer comprises a copolymer of n-isopropyl acrylamide.

14. The hydrophilic copolymer of claim 1 , wherein the hydrophilic copolymer comprises a copolymer of ethyl acrylamide.

Assignees

• Smith & Nephew
• Univ Sheffield

Inventors

• Hicks John Kenneth
• Hoskins Richard
• Rimmer Stephen
• Mcculloch Dorothy

Classifications

• C08J2375/04

  Polyurethanes · CPC title

• A61B2562/0295

  Strip shaped analyte sensors for apparatus classified in A61B5/145 or A61B5/157 · CPC title

• A61F13/00063

  comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic (drug delivery dressings A61K9/70; chemical aspect of the additives A61L15/00) · CPC title

• C08G18/73

  acyclic · CPC title

• C08J2433/14

  of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen · CPC title