Nitrated-fatty acids modulation of type II diabetes
US-10258589-B2 · Apr 16, 2019 · US
Reversible nitroxide derivatives of nitroalkenes that mediate nitrosating and alkylating reactions
US11491128B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11491128-B2 |
| Application number | US-202016995594-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 17, 2020 |
| Priority date | Oct 5, 2016 |
| Publication date | Nov 8, 2022 |
| Grant date | Nov 8, 2022 |
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- Title
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- Abstract
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- First independent claim
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Abstract
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Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include reversible nitroxide derivatives of nitroalkenes. The methods of various embodiments include administering an effective amount of any of these pharmaceutical compositions to a patient in need of treatment.
First claim
Opening claim text (preview).
What is claimed is: 1. A compound of Formula I: wherein R 1 is —NO 2 , R 2 is —ONO 2 , X 1 is —H; and X 2 is —COOH; and m and n are, independently, an integer from 1 to 10. 2. The compound of claim 1 , wherein the compound has a structure of: 3. A method of delivering nitric oxide comprising administering to a subject in need thereof an effective amount of the compound of claim 1 . 4. The method of claim 3 , wherein the compound has a structure of: 5. A method of treating inflammation, obesity, metabolic syndrome, acute kidney disease, or chronic kidney disease comprising administering to a subject in need thereof an effective amount of the compound of claim 1 . 6. The method of claim 5 , wherein negative side effects of a subject's gastrointestinal tract are reduced. 7. The method of claim 6 , wherein the side effects of the gastrointestinal tract is selected from the group consisting of diarrhea, cramping irritation, inflammatory bowel disease, colitis, and ulcers. 8. The method of claim 5 , wherein the compound has a structure of: 9. A method of inducing vasodilation comprising administering to a subject in need thereof an effective amount of the compound of claim 1 . 10. The method of claim 9 , wherein the compound has a structure of:
Assignees
Inventors
Classifications
- A61K31/201Primary
having one or two double bonds, e.g. oleic, linoleic acids · CPC title
Vasodilators for multiple indications · CPC title
with only carbon-to-carbon double bonds as unsaturation · CPC title
having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton · CPC title
of the kidneys · CPC title
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Frequently asked questions
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- What does patent US11491128B2 cover?
- Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include reversible nitroxide derivatives of nitroalkenes. The methods of various embodiments include administering an effective amount of any of these pharmaceutical compositions to a patient in need of treatment.
- Who is the assignee on this patent?
- Univ Of Pittsburgh—Of The Commonwealth System Of Higher Education
- What technology area does this patent fall under?
- Primary CPC classification A61K31/201. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Nov 08 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 7 related publications on this page (citations in our corpus or others sharing the same primary CPC).