Fatty acids as anti-inflammatory agents

Patent metadata

Field	Value
Publication number	US-9066902-B2
Application number	US-201013387489-A
Country	US
Kind code	B2
Filing date	Aug 2, 2010
Priority date	Jul 31, 2009
Publication date	Jun 30, 2015
Grant date	Jun 30, 2015

Abstract

Compounds of formula I and their metabolites are potent mediators of an inflammatory response: (I) where a, b, c, d, e, f, V, W, X, Y, R a , R a′ , R b , R b′ , R c , and R c′ are defined herein. In particular, the compounds of the invention are candidate therapeutics for treating inflammatory conditions.

First claim

What is claimed is:

1. A pharmaceutical formulation comprising: an effective amount of a compound having a formula of:

wherein:
R 1 is a heterocyclyl;
is an optional double bond;
W is —OH, —C(O)H, —C(O), —C(O)R p , —COOH, —COOR p , —Cl, —Br, —I, —CF 3 , —CN, —SO 3 , —SO 2 R p , —SO 3 H, —NH 3 + , —NH 2 R p+ , —NR p R q R t , —NO 2 , ═O, ═NR p…

Assignees

• Freeman Bruce A
• Schopfer Francisco J
• Univ Pittsburgh—Of The Commonwealth System Of Higher Education

Inventors

• Freeman Bruce A
• Schopfer Francisco J

Classifications

• A61P3/10

  Human Necessities · mapped topic

• A61P9/00

  Human Necessities · mapped topic

• A61P43/00

  Human Necessities · mapped topic

• A61P7/10

  Human Necessities · mapped topic

• A61P37/08

  Human Necessities · mapped topic