High cut-off hemodialysis membrane for use in liver dialysis

Patent metadata

Field	Value
Publication number	US-11478757-B2
Application number	US-201113578161-A
Country	US
Kind code	B2
Filing date	Apr 13, 2011
Priority date	Apr 20, 2010
Publication date	Oct 25, 2022
Grant date	Oct 25, 2022

Abstract

A system for liver dialysis makes use of a high cut-off hemodialysis membrane for removing water-soluble and protein-bound toxins from the blood of a person in need. A high cut-off hollow fiber hemodialysis membrane has improved potential to remove albumin-bound toxins and inflammatory mediators.

First claim

The invention claimed is:

1. A method for treatment of liver failure, the method comprising:
passing blood of a patient with liver failure into a dialysis device comprising a dialysis membrane that allows the passage of molecules having a molecular weight of up to 45 kDa with a sieving coefficient of about 0.1 to about 1.0 in the presence of whole blood, wherein the dialysis membrane has a sieving coefficient in plasma for albumin of from about 0.1 to about 0.2, and wherein the dialysis membrane has a sieving coefficient in plasma for myoglobin of from about 0.85 to about 1.0,
wherein the dialysis device comprises a dialysis side and a dialysate side, and
wherein dialysate on the dialysis side of the dialysis device is an albumin solution comprising human serum albumin at a concentration of from about 5% to about 12% by weight;
recycling the albumin solution by passing it through a low-flux dialyzer opposite of an aqueous buffered solution for the removal of water-soluble substances from the albumin solution;
passing the recycled albumin solution into the dialysate side of the dialysis device; and
returning the blood from the dialysis device to the patient.

2. The method for treatment of claim 1 , wherein the method reduces concentration of protein-bound toxins and inflammatory cytokines in blood of the patient.

3. The method for treatment of claim 1 , wherein the method reduces concentration of unconjugated bilirubin and bile acids in blood of the patient.

4. The method for treatment of claim 3 , wherein the reduction in concentration of unconjugated bilirubin is a reduction of about 47% after 6 hours of treatment.

5. The method for treatment of claim 3 , wherein the reduction in concentration of unconjugated bilirubin is about a 40% improvement in reduction of unconjugated bilirubin compared to a dialysis device comprising a high flux dialysis membrane.

6. The method for treatment of claim 1 , wherein at least one hydrophilic polymer and at least one hydrophobic polymer are present as domains on the surface of the dialysis membrane.

7. The method for treatment of claim 1 , wherein the dialysis membrane is a hollow fiber membrane and has at least a 3-layer asymmetric structure, wherein the at least 3-layer asymmetric structure comprises an innermost layer, and wherein the innermost layer comprises a separation.

8. The method for treatment of claim 7 , wherein the dialysis membrane has pores in the separation layer, said pores having a diameter in the range of about 15 to about 60 nm.

9. The method for treatment of claim 7 , wherein the dialysis membrane has pores in the separation layer, said pores having a diameter in the range of about 20 to about 40 nm.

10. The method for treatment of claim 1 , wherein the step of recycling the albumin solution further comprises passing it through an activated carbon adsorber, a filter for removing carbon particles, and an anion exchanger.

11. The method for treatment of claim 1 , wherein dialysate on the dialysis side of the dialysis device is an albumin solution comprising human serum albumin at a concentration of about 5% by weight.

12. The method for treatment of claim 1 , wherein dialysate on the dialysis side of the dialysis device is an albumin solution comprising human serum albumin at a concentration of about 10% by weight.

Assignees

• Storr Markus
• Krause Bernd
• Goehl Hermann
• Ertl Thomas
• Gekeler Alexander
• Gambro Lundia Ab

Inventors

• Storr Markus
• Krause Bernd
• Goehl Hermann
• Ertl Thomas
• Gekeler Alexander

Classifications

• A61M1/16

  with membranes · CPC title

• B01D69/08

  Hollow fibre membranes (manufacture of hollow fibres D01D5/24, D01F1/08) · CPC title

• B01D2325/20

  Specific permeability or cut-off range · CPC title

• A61M2210/1071

  Liver; Hepar · CPC title

• B01D71/68

  Polysulfones; Polyethersulfones · CPC title