Platelet activation and growth factor release using electric pulses
US-10369200-B2 · Aug 6, 2019 · US
Platelet activation and growth factor release using electric pulses
US11464829B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11464829-B2 |
| Application number | US-201916514662-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jul 17, 2019 |
| Priority date | Jan 17, 2014 |
| Publication date | Oct 11, 2022 |
| Grant date | Oct 11, 2022 |
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- Title
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Abstract
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Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for releasing growth factors, comprising: exposing a blood sample to a sequence of one or more electric pulses to trigger release of the growth factors in the blood sample, wherein the one or more electric pulses have an electric field strength between 0.1 kV/cm and 350 kV/cm and pulse durations between 1 nanosecond and 100 microsecond, wherein calcium chloride (CaCl2) is not added to the blood sample prior to or during the exposure of the blood sample to the sequence of one or more electric pulses, whereby the growth factor release is not accompanied by clotting within the blood sample; and collecting the released growth factors. 2. The method of claim 1 , wherein the blood sample was acquired from a patient. 3. The method of claim 1 , wherein the growth factors comprise platelet derived growth factors. 4. The method of claim 1 , wherein the blood sample comprises a whole blood sample or a platelet rich plasma. 5. The method of claim 1 , wherein a shape of the one or more electrical pulses is defined by user input or a stored protocol setting. 6. The method of claim 1 , further comprising: exposing the blood sample to a sensing signal having an electric field strength below the electric field strength of the one or more electric pulses prior to exposing the blood sample to the sequence of one or more electric pulses that trigger release of the growth factors in the blood sample. 7. The method of claim 6 , wherein the sensing signal is used to estimate a conductivity or a permittivity of the blood sample. 8. The method of claim 1 , wherein the collected growth factors are used for wound healing at a site of an injury.
Assignees
Inventors
Classifications
- G01N33/487Primary
of liquid biological material · CPC title
- A61K38/1858Primary
Platelet-derived growth factor [PDGF] · CPC title
by electrical means (G01N33/49, G01N33/493 take precedence) · CPC title
Apyrase (3.6.1.5), i.e. ATP diphosphohydrolase · CPC title
Platelets; Megacaryocytes · CPC title
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Frequently asked questions
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- What does patent US11464829B2 cover?
- Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
- Who is the assignee on this patent?
- Gen Electric
- What technology area does this patent fall under?
- Primary CPC classification G01N33/487. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Oct 11 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).