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Platelet activation and growth factor release using electric pulses
US10369200B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-10369200-B2 |
| Application number | US-201615252032-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 30, 2016 |
| Priority date | Jan 17, 2014 |
| Publication date | Aug 6, 2019 |
| Grant date | Aug 6, 2019 |
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Abstract
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Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
First claim
Opening claim text (preview).
The invention claimed is: 1. A method for releasing growth factors, comprising: exposing a blood sample to a sequence of one or more electric pulses that trigger release of a growth factor in the blood sample, wherein the growth factor release is not accompanied by clotting within the blood sample. 2. The method of claim 1 , comprising: collecting the growth factor; and treating a patient with the growth factor, wherein the blood sample was acquired from the patient. 3. The method of claim 1 , wherein calcium ions are not added to the blood sample prior to exposing the blood sample to the sequence of one or more electric pulses. 4. The method of claim 1 , wherein the method comprises increasing calcium ion concentration and adding an ADP blocking agent to the blood sample prior to exposing the blood sample to the sequence of one or more electric pulses. 5. The method of claim 4 , wherein the ADP blocking chemical comprises apyrase. 6. The method of claim 1 , wherein the one or more electric pulses have an electric field strength between about 0.1 kV/cm and about 350 kV/cm. 7. The method of claim 1 , wherein the one or more electric pulses have pulse durations between about 1 nanosecond and about 100 microseconds. 8. The method of claim 1 , wherein the growth factor comprises platelet derived growth factor. 9. The method of claim 1 , wherein the blood sample is a whole blood sample or a platelet rich plasma.
Assignees
Inventors
Classifications
- G01N33/487Primary
of liquid biological material · CPC title
Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents · CPC title
Platelets; Megacaryocytes · CPC title
- C12N13/00Primary
Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves · CPC title
by electrical means (G01N33/49, G01N33/493 take precedence) · CPC title
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- What does patent US10369200B2 cover?
- Methods and systems for releasing growth factors are disclosed. In certain embodiments, a blood sample is exposed to a sequence of one or more electric pulses to trigger release of a growth factor in the sample. In certain embodiments, the growth factor release is not accompanied by clotting within the blood sample.
- Who is the assignee on this patent?
- Gen Electric
- What technology area does this patent fall under?
- Primary CPC classification G01N33/487. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Aug 06 2019 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).