Ultrasonic cellular stimulation device

Patent metadata

Field	Value
Publication number	US-11447735-B2
Application number	US-201916660937-A
Country	US
Kind code	B2
Filing date	Oct 23, 2019
Priority date	Nov 22, 2018
Publication date	Sep 20, 2022
Grant date	Sep 20, 2022

Abstract

An ultrasonic cellular stimulation device includes: an ultrasonic transducer for generating a vibration wave; an upper cap having a fixing portion disposed on a lateral surface thereof; and a lower cap having a first surface and a second surface, and including: a recess indenting the first surface; an abutment portion located at a bottom of the recess; and an opening formed in the second surface and being in communication with the recess. The upper cap is partially received in the recess. The ultrasonic transducer is clamped and fixed between the fixing portion and the first surface. A glass piece is disposed on the abutment portion and fixed between the upper cap and the lower cap, such that the vibration wave is conveyed from the first surface into the abutment portion and the glass piece and a uniform and controllable sound field is generated above the glass piece.

First claim

What is claimed is:

1. An ultrasonic cellular stimulation device, comprising:
at least one ultrasonic transducer configured for generating a vibration wave; and
a lower cap having a first surface and a second surface corresponding to the first surface, and comprising:
a recess indenting the first surface of the lower cap;
an abutment portion located at a bottom of the recess; and
an opening formed in the second surface of the lower cap, the opening being in communication with the recess and having a diameter less than a diameter of the recess,

wherein the at least one ultrasonic transducer is disposed on the first surface around the recess of the lower cap, such that the vibration wave is conveyed from the first surface of the lower cap into the abutment portion.

2. The ultrasonic cellular stimulation device of claim 1 , further comprising an upper cap partially received in the recess of the lower cap and having at least one fixing portion on a lateral surface thereof.

3. The ultrasonic cellular stimulation device of claim 2 , wherein the at least one fixing portion of the upper cap is configured for clamping and fixing the at least one ultrasonic transducer between the at least one fixing portion and the first surface around the recess of the lower cap.

4. The ultrasonic cellular stimulation device of claim 2 , further comprising a glass piece disposed on the abutment portion in the recess of the lower cap, wherein a uniform and controllable sound field is formed on the glass piece when the vibration wave is conveyed into the abutment portion.

5. The ultrasonic cellular stimulation device of claim 4 , further comprising a reception portion concavely formed on the abutment portion around the opening in the recess of the lower cap and configured for receiving the glass piece.

6. The ultrasonic cellular stimulation device of claim 5 , further comprising an O-ring, wherein the upper cap has a flange, and the O-ring is coupled to an outer side of the flange and fixes the glass piece to the reception portion when the upper cap is received in the recess of the lower cap.

7. The ultrasonic cellular stimulation device of claim 4 , wherein the glass piece is a round glass piece having a diameter ranging from 10 mm to 40 mm and a thickness ranging from 0.15 mm to 0.4 mm.

8. The ultrasonic cellular stimulation device of claim 2 , wherein the upper cap and the lower cap are made of a rigid material.

9. The ultrasonic cellular stimulation device of claim 8 , wherein the rigid material is white steel or stainless steel.

10. The ultrasonic cellular stimulation device of claim 1 , wherein the at least one ultrasonic transducer is adhered to the first surface of the lower cap.

Assignees

• Univ Nat Taiwan

Inventors

• Wang Jaw-Lin
• Chu Ya-Cherng

Classifications

• C12M35/00 Primary

  Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion (machines for extracting juice from animal or plant tissue by electroplasmolysis A23N1/006, processes employing electric or wave energy B01J19/08; treatment of microorganisms or enzymes with electrical or wave energy C12N13/00; methods for cell fusion C12N15/02; introduction of foreign genetic material C12N15/87) · CPC title

• C12M35/04 Primary

  Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli · CPC title

• B06B1/0625

  Annular array · CPC title