Cell stimulating system

Patent metadata

Field	Value
Publication number	US-10260035-B2
Application number	US-201415306660-A
Country	US
Kind code	B2
Filing date	Nov 18, 2014
Priority date	Apr 30, 2014
Publication date	Apr 16, 2019
Grant date	Apr 16, 2019

Abstract

Provided is a cell stimulating system including an oscillator, in an ultrasound probe array type, including a plurality of ultrasound devices disposed in a matrix structure, the oscillator being produced using a micro electro mechanical system (MEMS), a plurality of cell containers configured to each contain a cell that is selectively stimulated by the ultrasound devices, the cell containers being disposed on a top of the oscillator to correspond to each of the ultrasound devices, and a device operator configured to operate an ultrasound device selected from among the ultrasound devices.

First claim

The invention claimed is:

1. A cell stimulating system, comprising:
an oscillator, in an ultrasound probe array type, including a plurality of ultrasound devices disposed in a matrix structure, the oscillator being produced using a micro electro mechanical system (MEMS);
a plurality of cell containers configured to each contain a cell that is selectively stimulated by the ultrasound devices, the cell containers being disposed on a top of the oscillator to correspond to each of the ultrasound devices; and
a device operator configured to operate an ultrasound device selected from among the ultrasound devices, wherein the device operator is configured to change the frequency of a wave of the ultrasound devices; and
wherein the device operator is configured to selectively operate the plurality of ultrasound devices such that an alternating current (AC) voltage having a resonance frequency of each of the plurality of ultrasound devices is applied to ultrasound devices disposed in one direction of the oscillator, and ultrasound devices disposed in another direction of the oscillator are used as grounds.

2. The system of claim 1 , wherein the ultrasound devices are arranged in a polygonal shape.

3. The system of claim 1 , wherein the oscillator includes:
a printed circuit board on which the ultrasound devices are disposed; and
an electrode configured to transmit a current to be applied to each of the ultrasound devices, the electrode being included in the printed circuit board to correspond to each of the ultrasound devices.

4. The system of claim 1 , wherein each of the cell containers includes:
a cell culture dish configured to contain the cell, the cell culture dish being disposed on a top of each of the ultrasound devices; and
a dish holder configured to hold the cell culture dish such that a bottom of the cell culture dish is adjacent to each of the ultrasound devices.

5. The system of claim 4 , wherein the cell culture dish hangs on a top of the dish holder such that the cell culture dish is disposed on the top of each of the ultrasound devices.

6. The system of claim 4 , wherein the dish holder is formed to have an open bottom such that the cell culture dish is in contact with each of the ultrasound devices.

7. The system of claim 1 , wherein the cell of each of the cell containers is selectively and simultaneously stimulated based on a plurality of parameters, by selective operation of the ultrasound devices of the oscillator by the device operator.

Assignees

• Daegu Gyeongbuk Inst Science & Tech

Inventors

• Choi Hong Soo
• Lee Won Jun
• Jung Joon Taek

Classifications

• C12N13/00

  Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves · CPC title

• C12M23/58

  Reaction vessels connected in series or in parallel (combinations of bioreactors with other apparatus, C12M43/00) · CPC title

• C12M35/04 Primary

  Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli · CPC title