Purgeable pharmaceutical fill needle

Patent metadata

Field	Value
Publication number	US-11439999-B2
Application number	US-202016858599-A
Country	US
Kind code	B2
Filing date	Apr 25, 2020
Priority date	Jul 22, 2011
Publication date	Sep 13, 2022
Grant date	Sep 13, 2022

Abstract

The present invention involves a fill needle system for aseptically dispensing a pharmaceutical fluid in an aseptic chamber comprises a fill needle tubing in fluid communication with a pharmaceutical fluid source via flexible tubing and extending through a fill needle hub; a fill needle dispensing tip disposed at a dispensing end of the fill needle tubing; a fill needle sheath shaped and arranged to removably mate with and seal aseptically to the fill needle hub to form an aseptically sealed volume enclosing the dispensing tip; and a fluid pressure pulse induction system disposed and configured to compress the flexible tubing in order to dislodge droplets of pharmaceutical fluid retained on the dispensing tip after halting dispensing of the pharmaceutical fluid. An associated method of dispensing pharmaceutical fluid comprises operating the fluid pressure pulse induction system to dislodge the droplets. The system may comprise a controller for automatically controlling the dispensing and droplet dislodging.

First claim

What is claimed is:

1. A fill needle for aseptically dispensing a pharmaceutical fluid in a chamber capable of maintaining an aseptic condition, the chamber having a pharmaceutical fluid source and a fluid pressure pulse induction system with associated flexible tubing, the fill needle comprising:
a fill needle hub,
a fill needle tubing in fluid communication with the pharmaceutical fluid source and extending through the fill needle hub;
a fill needle dispensing tip disposed at a dispensing end of the fill needle tubing;
a fill needle sheath shaped and arranged to removably mate with and seal aseptically to the fill needle hub to form an aseptically sealed volume enclosing the dispensing tip; and
a fill needle fluid ejector operably coupled to the fluid pressure induction system for manipulating the dispensing of the pharmaceutical fluid through the fill needle dispensing tip.

2. The fill needle of claim 1 , wherein the chamber includes a controller and further comprising a actuator configured to control the dispensing of the pharmaceutical fluid via the dispensing tip upon activation by the controller.

3. The fill needle of claim 2 , wherein the controller is configured to operate the fluid pressure pulse induction system to automatically compress the flexible tubing after halting dispensing of the pharmaceutical fluid.

4. The fill needle of claim 1 , wherein the fluid pressure pulse inducer is one of piezoelectrically actuated, electromechanically actuated, magnetically actuated, and pneumatically actuated.

5. The fill needle of claim 1 , wherein the fill needle fluid ejector includes a vibration actuator.

6. The fill needle of claim 5 , wherein the fill needle fluid ejector includes hydrophobic material proximate the vibration actuator.

7. The fill needle of claim 1 , wherein the fill needle fluid ejector includes a gas injector.

8. The fill needle of claim 7 , wherein the fill needle fluid ejector includes hydrophobic material proximate the gas injector.

9. The fill needle of claim 1 , wherein the fill needle fluid ejector includes a mechanism for squeezing the fill needle tubing.

10. The fill needle of claim 9 , wherein the fill needle fluid ejector further includes a bladder.

11. The fill needle of claim 10 , wherein the fill needle fluid ejector injects gas into the bladder.

12. The fill needle of claim 11 , wherein the bladder is disposed around the fill needle tubing proximate the fill needle dispensing tip.

13. The fill needle of claim 1 , wherein the fill needle fluid ejector includes a levered piezoelectric actuator.

14. The fill needle of claim 13 , wherein the fill needle fluid ejector includes a bladder, and the levered piezoelectric actuator is disposed to compress the bladder upon actuation.

15. The fill needle of claim 5 , wherein the vibration actuator is disposed to vibrate the fill needle tubing.

16. The fill needle of claim 5 , wherein the fill needle dispensing tip includes hydrophobic material.

17. The fill needle of claim 15 , wherein the fill needle tubing includes hydrophobic material proximate the vibration actuator.

18. The fill needle of claim 5 , wherein the vibration actuator is configured to be actuated electromechanically.

19. The fill needle of claim 5 , wherein the vibration actuator is configured to be actuated piezoelectrically.

20. The fill needle of claim 5 , wherein the vibration actuator is configured to be actuated by a controller.

Assignees

• Vanrx Pharmasystems Inc
• V Anrx Pharmasystems Inc

Inventors

• Cichy Marcin
• Naing Juvenal
• Diaz Guerrero Carlos Alberto

Classifications

• G01F15/007

  comprising means to prevent fraud · CPC title

• G01F11/00

  Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it · CPC title

• B01L2300/0609

  Holders integrated in container to position an object · CPC title

• B01L2200/141

  Preventing contamination, tampering · CPC title

• B01L2200/0689

  Sealing · CPC title