Purgeable pharmaceutical fill needle

Patent metadata

Field	Value
Publication number	US-11014696-B2
Application number	US-201715818986-A
Country	US
Kind code	B2
Filing date	Nov 21, 2017
Priority date	Jul 12, 2017
Publication date	May 25, 2021
Grant date	May 25, 2021

Abstract

A purgeable fill needle for dispensing pharmaceutical fluid into a pharmaceutical container comprises a fill needle hub, a fill needle tubing extending through the fill needle hub; a fill needle dispensing tip; a fill needle sheath removably mated with and seal aseptically to the fill needle hub to form an aseptically sealed volume enclosing the dispensing tip; and a terminal fluid ejector for removing fluid retained by the tip after halting dispensing of pharmaceutical fluid. The terminal fluid ejector may be based on automatic injection of an aseptic gas into the fill needle tubing, automated action of a gas bladder at the dispensing tip, or the automated operation of a compression actuator at the dispensing tip. The removal of terminal fluid retained at the tip after halting dispensing of the fluid may also be effected by automatically blowing attached droplets off the tip and automatically shaking the fill needle tubing.

First claim

What is claimed is:

1. A fill needle system for aseptically dispensing a pharmaceutical fluid, the system comprising:
a chamber capable of maintaining an aseptic condition;
a fill needle hub, a fill needle tubing in fluid communication with a pharmaceutical fluid source and extending through the fill needle hub;
a fill needle dispensing tip disposed at a dispensing end of the fill needle tubing, the fill needle dispensing tip configured to dispense fluid in a plurality of unattached droplets;
a fill needle sheath shaped and arranged to removably mate with and seal aseptically to the fill needle hub to form an aseptically sealed volume enclosing the dispensing tip; and
a terminal fluid ejector having means for exerting pressure on a single droplet of fluid within the dispensing tip such that the ejector is disposed and configured for removing a terminal pharmaceutical fluid portion from the dispensing tip.

2. The system of claim 1 , wherein the terminal fluid ejector comprises a gas channel in fluid communication with the dispensing tip via an orifice located in the fill needle tubing fluidwise immediately upstream from the dispensing tip.

3. The system of claim 2 , further comprising a gas source for supplying aseptic gas to the gas channel.

4. The system of claim 3 , further comprising a gas filter disposed to filter gas from the gas source in order to supply aseptic gas to the gas channel.

5. The system of claim 1 , wherein the terminal fluid ejector comprises a bladder disposed and arranged to remove the terminal pharmaceutical fluid portion from the dispensing tip when expanded under action of gas pressure.

6. The system of claim 1 , wherein the terminal fluid ejector comprises a flexible terminal tube and an electromechanical actuator disposed and arranged to compress the flexible terminal tube.

7. The system of claim 1 , wherein the terminal fluid ejector comprises a flexible terminal tube and a piezoelectric actuator disposed and arranged to compress the flexible terminal tube.

8. The system of claim 1 , wherein the terminal fluid ejector comprises a gas channel surrounding the fill needle tubing, the gas channel having an annular opening with respect to and proximate to the dispensing tip disposed to direct gas via the gas channel toward the dispensing tip.

9. The system of claim 1 , wherein the terminal fluid ejector comprises a vibration actuator disposed on the fill needle tubing and arranged for shaking the dispensing tip.

10. The system of claim 1 , further comprising a controller configured to control the dispensing of the pharmaceutical fluid via the dispensing tip.

11. The system of claim 10 , wherein the controller is configured to automatically operate the terminal fluid ejector to remove the terminal pharmaceutical fluid portion after halting the dispensing of the pharmaceutical fluid.

Assignees

• Vanrx Pharmasystems Inc

Inventors

• Diaz Guerrero Carlos Alberto

Classifications

• B65B55/10 Primary

  by liquids or gases · CPC title

• B65B7/161

  Sealing filled ampoules · CPC title

• B65B7/2821

  applying plugs or threadless stoppers (for bottles or jars B67B1/04) · CPC title

• B65B57/02

  responsive to absence, presence, abnormal feed, or misplacement of binding or wrapping material, containers, or packages · CPC title

• B65B43/60

  rotatable · CPC title