Formed sheet product and hemostatic material
US-10485894-B2 · Nov 26, 2019 · US
US11433160B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11433160-B2 |
| Application number | US-201916659830-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 22, 2019 |
| Priority date | May 14, 2012 |
| Publication date | Sep 6, 2022 |
| Grant date | Sep 6, 2022 |
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A formed sheet product of a polymer composition comprising at least one protein selected from the group consisting of fibrinogen and thrombin and at least one polymer selected from the group consisting of an aliphatic polyester and a water-soluble polymer, and a laminated formed sheet product comprising a first polymer composition layer composed of fibrinogen and a water-soluble polymer and a second polymer composition layer composed of thrombin and an aliphatic polyester are provided. These formed products are applied onto a wound site and function as a hemostatic material.
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The invention claimed is: 1. A formed sheet product of a polymer composition comprising at least one protein selected from the group consisting of fibrinogen and thrombin, and an aliphatic polyester, wherein at least one part of said at least one protein is incorporated into and is not covalently bonded to said aliphatic polyester, and wherein the formed sheet product is manufactured from a suspension composed of a solution of the aliphatic polyester and particles of the protein. 2. The formed sheet product according to claim 1 , wherein the aliphatic polyester is selected from the group consisting of polyglycolic acid, polylactic acid, polycaprolactone, a copolymer thereof, and a mixture thereof. 3. The formed sheet product according to claim 1 , wherein the formed sheet product is a formed film product or a formed fiber product. 4. A hemostatic material comprising the formed sheet product according to claim 1 . 5. A tissue adhesive material or tissue closure material comprising the formed sheet product according to claim 1 .
Porous materials, e.g. foams or sponges · CPC title
Materials resorbable by the body · CPC title
Peptides having up to 20 amino acids in a defined sequence · CPC title
Thrombin (3.4.21.5) · CPC title
Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution · CPC title
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