Mixture of polymers, lubricating fluid and porous materials comprising said mixture, and surface bearing said mixture

Patent metadata

Field	Value
Publication number	US-11426490-B2
Application number	US-202117189144-A
Country	US
Kind code	B2
Filing date	Mar 1, 2021
Priority date	Apr 22, 2016
Publication date	Aug 30, 2022
Grant date	Aug 30, 2022

Abstract

A mixture of polymers with lubricating properties is provided. The polymer can be used to produce a lubricating fluid. They can also be born on a surface or embedded in a porous material. This mixture of polymers comprises (a) a pharmaceutically acceptable bottle-brush polymer comprising a backbone with polymeric pendant chains, and (b) a pharmaceutically acceptable linear polymer. In the lubricating fluid, the bottle-brush polymer and the linear polymer are dissolved together in a pharmaceutically acceptable solvent.

First claim

What is claimed is:

1. A method of treating a disease having a degenerative mechanical component, the method comprising administering a lubricating fluid to a tissue affected by the disease, wherein the lubricating fluid comprises:
a bottle-brush polymer comprising a polymeric backbone with polymeric pendant chains with capping blocks bearing amine groups attached at both ends of said backbone,
wherein the polymeric backbone with polymeric pendant chains form a copolymer of formula:

and
a linear polymer which is hyaluronic acid or poly(vinylpyrrolidone) or a pharmaceutically acceptable salt thereof,
the bottle-brush polymer and the linear polymer being dissolved together in a solvent.

2. The method of claim 1 , wherein the disease is osteoarthritis, a lacrimal fluid production deficiency, or vaginal dryness.

3. The method of claim 2 , wherein the disease is osteoarthritis.

4. The method of claim 1 , wherein the lubricating fluid is administered by injection.

5. The method of claim 1 , wherein the grafting ratio of the bottle-brush polymer is between about 40 and about 60%.

6. The method of claim 1 , wherein the linear polymer is partially crosslinked.

7. The method of claim 1 , wherein the solvent is saline.

8. The method of claim 1 , wherein the lubricating fluid further comprises one or more therapeutic agent.

9. A synthetic synovial fluid comprising:
a bottle-brush polymer comprising a polymeric backbone with polymeric pendant chains with capping blocks bearing amine groups attached at both ends of said backbone,
wherein the polymeric backbone with polymeric pendant chains form a copolymer of formula:

and
a linear polymer which is hyaluronic acid or poly(vinylpyrrolidone) or a pharmaceutically acceptable salt thereof,
the bottle-brush polymer and the linear polymer being dissolved together in a solvent.

10. The synthetic synovial fluid of claim 9 , being for the treatment of osteoarthritis.

11. The synthetic synovial fluid of claim 9 , wherein the grafting ratio of the bottle-brush polymer is between about 40 and about 60%.

12. The synthetic synovial fluid of claim 9 , wherein the linear polymer is partially crosslinked.

13. The synthetic synovial fluid of claim 9 , further comprising one or more therapeutic agent.

14. The synthetic synovial fluid of claim 9 , wherein the solvent is saline.

15. A method of lubricating a tissue of a living body, the method comprising the step of contacting a lubricating fluid with said tissue, wherein the lubricating fluid comprises:
a bottle-brush polymer comprising a polymeric backbone with polymeric pendant chains with capping blocks bearing amine groups attached at both ends of said backbone,
wherein the polymeric backbone with polymeric pendant chains form a copolymer of formula:

and
a linear polymer which is hyaluronic acid or poly(vinylpyrrolidone) or a pharmaceutically acceptable salt thereof,
the bottle-brush polymer and the linear polymer being dissolved together in a solvent.

16. The method of claim 15 , wherein the tissue is an eye, skin, a surface of a ligament, a vagina, a joint, a gastrointestinal tract, a nasal duct, a tracheal duct, or a stomach.

17. The method of claim 16 , wherein the tissue is a joint.

18. The method of claim 15 , wherein the grafting ratio of the bottle-brush polymer is between about 40 and about 60%.

19. The method of claim 15 , wherein the linear polymer is partially crosslinked.

20. The method of claim 15 , wherein the lubricating fluid further comprises one or more therapeutic agent.

Assignees

• Valorisation Rech Limited Partnership
• Valorisation Hsj Lp
• Univ Carnegie Mellon

Inventors

• Banquy Xavier
• Faivre Jimmy
• Shrestha Buddha Ratna
• Matyjaszewski Krzysztof
• Burdynska Joanna
• Moldovan Florina

Classifications

• A61L27/16

  obtained by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• C08F220/14

  Methyl esters {, e.g. methyl (meth)acrylate} · CPC title

• A61L27/50 Primary

  Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials} · CPC title

• A61L2400/10

  Materials for lubricating medical devices · CPC title

• C10M2225/025

  used as base material · CPC title