Bottlebrush polymer compositions, lubricating fluid, porous materials comprising said compositions, and surface bearing said compositions

Patent metadata

Field	Value
Publication number	US-10933166-B2
Application number	US-201716095051-A
Country	US
Kind code	B2
Filing date	Apr 13, 2017
Priority date	Apr 22, 2016
Publication date	Mar 2, 2021
Grant date	Mar 2, 2021

Abstract

A mixture of polymers with lubricating properties is provided. The polymer can be used to produce a lubricating fluid. They can also be born on a surface or embedded in a porous material. This mixture of polymers comprises (a) a pharmaceutically acceptable bottle-brush polymer comprising a backbone with polymeric pendant chains, and (b) a pharmaceutically acceptable linear polymer. In the lubricating fluid, the bottle-brush polymer and the linear polymer are dissolved together in a pharmaceutically acceptable solvent.

First claim

The invention claimed is:

1. A lubricating fluid comprising:
a. a bottle-brush polymer comprising a polymeric backbone with polymeric pendant chains with capping blocks bearing amine groups attached at both ends of said backbone,
wherein the polymeric backbone with polymeric pendant chains form a copolymer of formula:

and
b. a linear polymer which is hyaluronic acid or poly(vinylpyrrolidone) or a pharmaceutically acceptable salt thereof,

the bottle-brush polymer and the linear polymer being dissolved together in a solvent.

2. The lubricating fluid according to claim 1 , wherein the linear polymer is partially crosslinked.

3. The lubricating fluid according to claim 1 , comprising the bottle-brush polymer and the linear polymer in a bottle-brush polymer:linear polymer weight ratio between about 1:1 and about 1:20.

4. The lubricating fluid according to claim 1 , wherein the bottle-brush polymer has a grafting ratio between about 40% and about 60%.

5. The lubricating fluid according to claim 1 , wherein the molecular weight of the backbone is between about 10 kDa and about 100 kDa.

6. The lubricating fluid according to claim 1 , wherein the molecular weight of the pendant chain is between about 1 kDa and about 15 kDa.

7. The lubricating fluid according to claim 1 , wherein the concentration of the bottle-brush polymer in the lubricating fluid is between about 1 ug/ml and about 0.1 mg/mL.

8. The lubricating fluid according to claim 1 , wherein the linear polymer has a molecular weight between about 5 kDa and or about 5 MDa.

9. The lubricating fluid according to claim 1 , wherein the concentration of linear polymer in the lubricating fluid is between about 0.001 mg/mL and about 0.01 mg/mL.

10. The lubricating fluid according to claim 1 , wherein the solvent is saline.

11. A surface bearing a polymeric layer, the polymeric layer comprising:
a. a bottle-brush polymer comprising a polymeric backbone with polymeric pendant chains with capping blocks bearing amine groups attached at both ends of said backbone,
wherein the polymeric backbone with polymeric pendant chains form a copolymer of formula:

and
b. a linear polymer which is hyaluronic acid or poly(vinylpyrrolidone) or a pharmaceutically acceptable salt thereof.

12. The surface of claim 11 , being a surface of an ophthalmic lens, a surface of the barrel of a syringe, a surface of an injection device, a surface of an elution device, or a surface of an implant.

13. The surface of claim 12 , where the surface is a surface of a contact lens.

14. The surface of claim 11 , wherein the polymeric layer releases the bottle-brush polymer and the linear polymer when the surface contacts a solvent.

15. A porous material having embedded therein:
a. a bottle-brush polymer comprising a polymeric backbone with polymeric pendant chains with capping blocks bearing amine groups attached at both ends of said backbone,
wherein the polymeric backbone with polymeric pendant chains form a copolymer of formula:

and
b. a linear polymer which is hyaluronic acid or poly(vinylpyrrolidone) or a pharmaceutically acceptable salt thereof.

16. The porous material of claim 15 , wherein the porous material is a gel, a sponge, a textile or textile fibers.

17. The porous material of claim 15 , wherein the porous material is a contact lens.

Assignees

• Valorisation Rech Limited Partnership
• Valorisation Hsj Lp
• Univ Carnegie Mellon

Inventors

• Banquy Xavier
• Faivre Jimmy
• Shrestha Buddha Ratna
• Matyjaszewski Krzysztof
• Burdynska Joanna
• Moldovan Florina

Classifications

• C08F220/14

  Methyl esters {, e.g. methyl (meth)acrylate} · CPC title

• C08L51/003

  grafted on to macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds (C08L51/04, C08L51/06 take precedence) · CPC title

• C08F2438/01

  Atom Transfer Radical Polymerization [ATRP] or reverse ATRP · CPC title

• C10M107/44

  Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• C08L5/08

  Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof · CPC title