Systems for administering electrical stimulation to treat cancer

Patent metadata

Field	Value
Publication number	US-11420049-B2
Application number	US-202016850720-A
Country	US
Kind code	B2
Filing date	Apr 16, 2020
Priority date	Apr 22, 2019
Publication date	Aug 23, 2022
Grant date	Aug 23, 2022

Abstract

Embodiments herein relate to a medical device for treating a cancerous tumor, including an electric field generating circuit configured to generate one or more electric fields at or near a site of the cancerous tumor and control circuitry in communication with the electric field generating circuit. The medical device includes one or more supply wires in electrical communication with the electric field generating circuit and one or more supply electrodes. The supply electrodes are configured to deliver an electric field at or near the site of the cancerous tumor. The medical device can include one or more sensing wires in electrical communication with the control circuitry and one or more sensing electrodes. The sensing electrodes can be configured to measure an impedance of the cancerous tumor at at least two different electric field strengths. Other embodiments are also included herein.

First claim

The claims are:

1. A medical device for treating a cancerous tumor comprising:
an electric field generating circuit configured to generate one or more electric fields at or near a site of the cancerous tumor;
control circuitry in communication with the electric field generating circuit, the control circuitry configured to control delivery of the one or more electric fields from the electric field generating circuit;
wherein the control circuitry is configured to generate at least a first electric field and a second electric field, wherein the first electric field has a first electric field strength and the second electric field has a second electric field strength;
a first supply wire in communication with a first supply electrode and a second supply wire in communication with a second supply electrode, the first and second supply wires in electrical communication with the electric field generating circuit, wherein a current generated by the electric field generating circuit flows through the first supply wire and the second supply wire, wherein the first and second supply electrodes are configured to deliver the first electric field and second electric field at or near the site of the cancerous tumor; and
a first sensing wire in communication with a first sensing electrode and a second sensing wire in communication with a second sensing electrode, the first and second sensing wires in electrical communication with the control circuitry, wherein substantially none of the current generated by the electric field generating circuit flows through the first sensing wire and the second sensing wire;
wherein the one or more sensing electrodes are configured to measure an impedance of the cancerous tumor at the first electric field strength and at the second electric field strength during application of the first electric field and second electric field;
wherein the first electric field strength is selected from a range of from 0.1 V/cm to 2 V/cm and the second electric field strength is selected from a range of from 3 V/cm to 100 V/cm.

2. The medical device of claim 1 , wherein the second electric field strength is greater than the first electric field strength.

3. The medical device of claim 1 , further comprising a memory comprising one or more therapeutic parameter sets.

4. The medical device of claim 3 , wherein the control circuitry is further configured to implement the one or more therapeutic parameter sets to deliver a given therapy.

5. The medical device of claim 4 , wherein the control circuitry is configured to modulate the one or more electric fields if the impedance at or near the site of the cancerous tumor changes by at least 5% during a therapy relative to an initial impedance at or near the site of the cancerous tumor at a beginning of the given therapy.

6. The medical device of claim 5 , wherein the one or more electric fields is modulated by increasing or decreasing the electric field strength.

7. The medical device of claim 1 , wherein the control circuitry causes the electric field generating circuit to generate the one or more electric fields at frequencies selected from a range of from 10 kHz to 1 MHz at or near a site of the cancerous tumor.

8. The medical device of claim 1 , wherein the control circuitry is further configured to generate the one or more electric fields by sweeping through a range of frequencies, wherein sweeping through a range of frequencies comprises sweeping from a first frequency up to a second frequency and sweeping from the second frequency down to the first frequency, wherein the second frequency is higher than the first frequency.

9. The medical device of claim 8 , wherein the range of frequencies comprises a range of frequencies of from 100 kHz to 500 kHz.

10. The medical device of claim 1 , further comprising a first lead housing the first supply wire, a second lead housing the first sensing wire, a third lead housing the second supply wire, and a fourth lead housing second sensing wire.

11. The medical device of claim 10 , wherein the first supply electrode and the second supply electrode are configured deliver an electric field along a first vector at or near the site of the cancerous tumor, and the first sensing electrode and the second sensing electrode measure an impedance of the cancerous tumor along a second vector at or near the site of the cancerous tumor, wherein the first vector and second vector are spatially and/or directionally distinct from one another.

12. The medical device of claim 11 , wherein the second lead further comprises a third sensing wire, wherein the third sensing wire is in communication with a third sensing electrode; and wherein the fourth lead further comprises a fourth sensing wire, wherein the fourth sensing wire is in electrical communication with a fourth sensing electrode; wherein the third sensing electrode and the fourth sensing are configured to sense an impedance of a healthy tissue near the cancerous tumor.

Assignees

• Boston Scient Scimed Inc

Inventors

• Schmidt Brian L
• Stein Benjamin Keith
• Maile Keith R
• Linder William J
• Balczewski Ron A
• Gruba Sarah Melissa
• Nelson Tucker James
• Kharam Aleksandra

Classifications

• A61N1/36002 Primary

  Cancer treatment, e.g. tumour · CPC title

• A61N1/05

  for implantation or insertion into the body, e.g. heart electrode (A61N1/06 takes precedence) · CPC title

• A61N1/378

  Electrical supply · CPC title

• A61N1/40

  Applying electric fields by inductive or capacitive coupling (microwave apparatus A61N5/00); {Applying radio-frequency signals} · CPC title

• A61N1/3614

  based on impedance measurement · CPC title