Plasmonic assisted systems and methods for interior energy-activation from an exterior source

Patent metadata

Field	Value
Publication number	US-9630022-B2
Application number	US-201414165026-A
Country	US
Kind code	B2
Filing date	Jan 27, 2014
Priority date	Apr 8, 2007
Publication date	Apr 25, 2017
Grant date	Apr 25, 2017

Abstract

A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent.

First claim

The invention claimed is:

1. A method for curing a radiation-curable medium disposed in an animal or a human, comprising:
(1) disposing said radiation-curable medium in the animal or the human;
(2) placing inside the radiation-curable medium at least one energy modulation agent and at least one photoactivatable agent, said energy modulation agent comprising a photon emitter which emits at least one of ultraviolet and visible light into the radiation-curable medium upon interaction with an initiation energy;
(3) applying the initiation energy from an energy source including at least one of x-rays, gamma rays, or an electron beam to the radiation-curable medium in order to provide said at least one of ultraviolet and visible light inside the radiation-curable;
(4) inducing, from the light emitted into the radiation-curable medium, a photoreactive change which cures the radiation-curable medium; and
(5) forming a radiation-cured medium at least at a local point in the animal or the human.

2. The method of claim 1 , wherein said forming a radiation-cured medium comprises closing a hole or pathway in the animal or the human.

3. The method of claim 1 , wherein said forming a radiation-cured medium comprises closing a hole or pathway in an internal organ of the animal or the human.

4. The method of claim 1 , wherein said inducing a photoreactive change comprises emitting said ultraviolet light from the energy modulation agent to cure the radiation-curable medium.

5. The method of claim 1 , wherein said inducing a photoreactive change comprises emitting said visible light from the energy modulation agent to cure the radiation-curable medium.

6. The method of claim 1 , wherein said applying the initiation energy comprises applying the initiation energy from a focused source.

7. The method of claim 1 , wherein said applying the initiation energy comprises directing one or more focused beams of x-rays into the radiation-curable medium.

8. The method of claim 7 , wherein said directing one or more focused beams of x-rays comprises generating regions of overlapped exposure in the radiation-curable medium.

9. The method of claim 1 , wherein said applying the initiation energy comprises generating said at least one of ultraviolet and visible light at local regions inside the radiation-curable medium.

10. The method of claim 1 , wherein said forming a radiation-cured medium comprises localizing the curing in the radiation curable medium.

11. The method of claim 10 , wherein said localizing the curing comprises placing in the radiation-curable medium optically dense materials to reduce propagation of said at least one of ultraviolet and visible light.

12. The method of claim 1 , wherein said placing inside the medium comprises providing optically dense materials in the radiation-curable medium.

13. The method of claim 1 , wherein said placing inside the medium comprises providing color pigments in the radiation-curable medium.

14. The method of claim 1 , wherein said placing inside the medium comprises providing a plasmonics agent in the radiation-curable medium.

15. The method of claim 14 , wherein the plasmonics agent comprises a metal structure.

16. The method of claim 15 , wherein the metal structure comprises a metal disposed on the energy modulation agent.

17. The method of claim 15 , wherein the metal structure comprises a metal partially coated on the energy modulation agent.

18. The method of claim 14 , wherein the plasmonics agent comprises a plurality of metal nanoparticles disposed in vicinity of each other.

19. The method of claim 1 , wherein the energy modulation agent comprises at least one of Y 2 O 3 ; ZnS; ZnSe; MgS; CaS; Mn, Er ZnSe; Mn, Er MgS; Mn, Er CaS; Mn, Er ZnS; Mn,Yb ZnSe; Mn,Yb MgS; Mn, Yb CaS; Mn,Yb ZnS:Tb 3+ , Er; 3+ ; ZnS;Tb 3+ :Y 2 O 3 :Tb 3+ ; Y 2 O 3 :Tb 3+ , Er 3+ ; ZnS:Mn 2+ ; ZnS:Mn,Er 3+ .

20. The method of claim 1 , wherein said inducing a photoreactive change comprises activating a photoinitiator in the radiation-curable medium.

21. The method of claim 1 , wherein said placing inside the medium comprises placing inside the medium a plurality of luminescent agents for said at least one energy modulation agent.

22. The method of claim 21 , wherein the luminescent agents comprise at least one of phosphorescent compounds and fluorescent molecules.

23. The method of claim 1 , wherein said placing inside the medium comprises placing plural energy modulation agents throughout the radiation-curable medium.

24. The method of claim 1 , wherein said placing inside the medium comprises providing encapsulations of plural energy modulation agents in the radiation-curable medium.

25. The method of claim 1 , wherein said applying the initiation energy comprises applying x-ray energy.

26. The method of claim 1 , wherein said placing inside the medium comprises providing plural energy modulation agents at a density where said at least one of ultraviolet and visible light is not occluded throughout the radiation-curable medium.

27. The method of claim 25 , wherein the x-ray energy is in a range from 10 to 150 keV.

28. The method of claim 1 , wherein said applying the initiation energy comprises applying electron beams from an electron beam source.

29. The method of claim 1 , wherein said applying the initiation energy comprises delivering a beam of radiation to a pre-selected coordinate.

30. The method of claim 1 , wherein said forming a radiation-cured medium comprises forming a prosthetic device in the animal or the human.

31. The method of claim 1 , wherein said disposing said radiation-curable medium comprises disposing said radiation-curable medium in a structure holding the radiation-curable medium.

32. The method of claim 1 , wherein said disposing said radiation-curable medium comprises disposing said radiation-curable medium in a structure at least partially enclosing the uncured radiation-curable medium.

33. The method of claim 32 , wherein the structure is opaque to visible light.

34. The method of claim 1 , wherein said disposing said radiation-curable medium comprises pumping the radiation curable medium into a region to be filled with the radiation curable medium.

35. The method of claim 1 , wherein said disposing said radiation-curable medium comprises disposing for said radiation-curable medium a biocompatible polymer.

36. The method of claim 35 , wherein said disposing a biocompatible polymer comprises disposing at least one of polymers, natural polymers, poly(esters) based on polylactide (PLA), polyglycolide (PGA), polycarpolactone (PCL), and copolymers thereof.

37. The method of claim 35 , wherein said disposing a biocompatible polymer comprises disposing at least one of poly(hydroxyalkanoate)s poly(saccharide)s, polyethylene oxides, poly(ether)(ester) block copolymers, ethylene vinyl acetate copolymers, a starch, a cellulose, and a chitosan.

38. The method of claim 1 , wherein said disposing said radiation-curable medium comprises disposing for said radiation-curable medium luminescent polymers.

39. The method of claim 38 , wherein disposing luminescent polymers comprises disposing at least one of poly(phenylene ethyny

Assignees

• Immunolight Llc
• Univ Duke

Inventors

• Bourke Jr Frederic Avery
• Vo-Dinh Tuan

Classifications

• A61P35/00

  Antineoplastic agents · CPC title

• A61P31/18

  for HIV · CPC title

• A61P7/08

  Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock (artificial tears A61P27/04) · CPC title

• A61P31/04

  Antibacterial agents · CPC title

• A61L2/088

  using photocatalysts or photosensitisers · CPC title