Frequency-domain optical interferometry imaging apparatus and method for astigmatistic bi-focal illumination imaging of an eye

Patent metadata

Field	Value
Publication number	US-11415407-B2
Application number	US-202017036295-A
Country	US
Kind code	B2
Filing date	Sep 29, 2020
Priority date	Apr 1, 2016
Publication date	Aug 16, 2022
Grant date	Aug 16, 2022

Abstract

Embodiments of the present invention provide a method and apparatus for frequency-domain optical interferometry imaging. Embodiments of the invention include an apparatus comprising a line-shaping optical element for directing optical radiation into a line illumination, an imaging optical element for receiving optical radiation comprising radiation reflected from a target sample and a reference point associated with the target sample, and a detection unit for measuring common path interferences between a plurality of reflections from the target sample and the reference point. Embodiments of the invention include a method comprising directing radiation into a line illumination, directing the line illumination towards a target sample, receiving radiation reflected from the target sample at a detection unit, and measuring common path interferences between a plurality of reflections at the target sample and a reference point.

First claim

The invention claimed is:

1. An apparatus for frequency-domain optical interferometry imaging, comprising:
a line-shaping optical element for directing optical radiation into a line illumination;
an imaging lens for receiving optical radiation comprising radiation reflected from a target sample and a reference point; and
a detector for measuring interferences between a plurality of reflections from the target sample and the reference point;
wherein the line-shaping optical element and the imaging lens are moveably mounted; and
wherein the line-shaping optical element and the imaging lens are arranged such that F x , the distance between the focal point of the line-shaping optical element and the imaging lens is

F
x

=

1

1

F

o
⁢
b
⁢
j

-

1

F

o
⁢
b
⁢
j

+

Δ
⁢
F

where F obj is the focal length of the imaging lens, and ΔF is the difference in depth between two illumination focal points in two lateral dimensions perpendicular to a direction of travel of light, caused by the interaction of the line-shaping optical element and the imaging lens.

2. The apparatus of claim 1 , wherein the line-shaping optical element is a cylindrical or acylindrical lens.

3. The apparatus of claim 1 , further comprising a beam splitting means to direct at least a portion of the radiation.

4. The apparatus of claim 3 , wherein the imaging lens is positioned between the detector and the beam splitting means.

5. The apparatus of claim 1 , wherein the apparatus comprises one or more of a wave guide, a collimator lens, a beam splitting means, and/or an optical filter.

6. The apparatus of claim 1 , wherein the imaging lens comprises a spherical or aspherical lens.

7. The apparatus of claim 1 , wherein the imaging lens comprises a reflective or refractive lens.

8. The apparatus of claim 1 , wherein the imaging lens is one of a plurality of imaging lenses.

9. The apparatus of claim 1 , wherein the detector comprises a spectrograph.

10. The apparatus of claim 1 , wherein the detector comprises one of a CCD, CMOS or sCMOS array.

11. The apparatus of claim 1 , wherein the reference point is a point on a surface of the target sample.

12. The apparatus of claim 1 , wherein the reference point is a point within the target sample.

13. The apparatus of claim 1 , wherein the reference point is one of a plurality of reference points taken simultaneously.

14. The apparatus of claim 1 , wherein the optical radiation is provided by multiple sources of optical radiation.

15. The apparatus of claim 1 , further comprising means for moving a position of one or more of the line-shaping optical element and the imaging optical element to change a focal point of the associated optical element.

16. The apparatus as claimed in claim 1 , wherein the detection unit is configured for measuring common path interferences between the plurality of reflections from the target sample and the reference point.

17. The apparatus as claimed in claim 1 , wherein the reference point is associated with the target sample.

18. A method for frequency-domain optical interferometry imaging, comprising:
Directing, with a line-shaping optical element, radiation into a line illumination;
directing the line illumination towards a target sample;
receiving, via an imaging lens, radiation reflected from the target sample at a detector; and
measuring interferences between a plurality of reflections at the target sample and a reference point
wherein the line-shaping optical element and the imaging lens are moveably mounted; and
wherein the line-shaping optical element and the imaging lens are arranged such that F x , the distance between the focal point of the line-shaping optical element and the imaging lens is

F
x

=

1

1

F
obj

-

1

F
obj

+

Δ
⁢

⁢
F

where F obj is the focal length of the imaging lens, and ΔF is the difference in depth between two illumination focal points in two lateral dimensions perpendicular to a direction of travel of light, caused by the interaction of the line-shaping optical element and the imaging lens.

19. The method of claim 18 , further comprising forming tomographic images from the measured interference readings.

20. The method of claim 18 , comprising directing the radiation into a line illumination via a cylindrical or acylindrical lens.

21. The method of claim 18 , comprising directing at least a portion of the radiation via a beam splitting means.

22. The method of claim 18 , comprising further directing the radiation via a wave guide, a collimator lens, and/or an optical filter.

23. The method of claim 21 , wherein the radiation is directed towards the target sample and the detector via the beam splitting means.

24. The method of claim 18 , wherein the radiation is directed via a plurality of imaging lenses.

25. The method of claim 18 , wherein the reference point is a point on the surface of the target sample.

26. The method of claim 18 , wherein the reference point is a point within the target sample.

27. The method of claim 18 , wherein the reference point is a point taken from a reflective surface external to the target sample.

28. The method of claim 18 , wherein the radiation is provided by multiple sources.

29. The method of claim 18 , comprising moving a position of one or more of the line-shaping optical element and the imaging lens to change a focal point of the associated optical element.

Assignees

• Univ Liverpool

Inventors

• Shen Yaochun
• Zheng Yalin
• Dong Yue
• Lawman Samuel

Classifications

• A61B3/102

  for optical coherence tomography [OCT] · CPC title

• G01B9/02044

  Imaging in the frequency domain, e.g. by using a spectrometer · CPC title

• A61B3/12

  for looking at the eye fundus, e.g. ophthalmoscopes (A61B3/13 takes precedence) · CPC title

• G01B9/02037

  by generating a transverse line focus · CPC title

• A61B3/14

  Arrangements specially adapted for eye photography · CPC title