Bioprocessing vessel

Patent metadata

Field	Value
Publication number	US-11414639-B2
Application number	US-201916968306-A
Country	US
Kind code	B2
Filing date	Feb 8, 2019
Priority date	Feb 9, 2018
Publication date	Aug 16, 2022
Grant date	Aug 16, 2022

Abstract

A bioreactor vessel includes a bottom plate, a vessel body coupled to the bottom plate, the vessel body and the bottom plate defining an interior compartment therebetween, and a plurality of recesses formed in the bottom plate, each recess of the plurality of recesses being configured to receive a corresponding alignment pin on a bed plate for aligning the bioreactor vessel on the bed plate.

First claim

What is claimed is:

1. A bioreactor vessel, comprising:
a bottom plate;
a vessel body coupled to the bottom plate, the vessel body and the bottom plate defining an interior compartment therebetween; and
a plurality of recesses formed in the bottom plate, each recess of the plurality of recesses being configured to receive a corresponding alignment pin protruding from a bed plate of a processing chamber tray and configured to align the bioreactor vessel on the bed plate.

2. The bioreactor vessel of claim 1 , wherein:
the bottom plate is generally rectangular in shape; and
wherein the plurality of recesses is four recesses, each recess of the four recesses being located adjacent to a respective corner of the bottom plate.

3. The bioreactor vessel of claim 1 , wherein:
the plurality of recesses are generally cylindrical in shape and have a generally dome-shaped interior surface;
wherein a diameter of the recesses is greater than a diameter of the alignment pins to allow for tilting of the bioreactor vessel when the alignment pins are received in the recesses.

4. The bioreactor vessel of claim 3 , wherein:
the recesses and the alignment pins are dimensioned such that when each alignment pin contacts the domed shaped interior surface of a respective recess, the bioreactor vessel is in a level state.

5. The bioreactor vessel of claim 1 , further comprising:
a position verification structure formed on a bottom surface of the bottom plate, the position verification structure being configured to interact with a sensor on the bed plate to allow for a determination of a position of the bioreactor vessel with respect to the bed plate.

6. The bioreactor vessel of claim 5 , wherein:
the position verification structure is a beam break and the sensor is an optical beam above a surface of the bed plate;
wherein the beam break is configured to break or interrupt the optical beam when the bioreactor vessel is seated on the bed plate.

7. The bioreactor vessel of claim 1 , further comprising:
at least one engagement surface formed on a bottom surface of the bottom plate adjacent to an edge of the bottom plate, the at least one engagement surface being configured to engage a cam arm of a tilting mechanism that is selectively extendable above the bed plate to enable tilting of the bioreactor vessel with respect to the bed plate.

8. The bioreactor vessel of claim 7 , wherein:
the bioreactor vessel is configured to tilt about an axis defined by a joint formed by one of the plurality of recesses in the bottom plate and a corresponding alignment pin on the bed plate.

9. The bioreactor vessel of claim 1 , wherein:
the at least one engagement surface is two engagement surfaces offset from a center line of the bottom plate.

10. The bioreactor vessel of claim 9 , wherein:
the two engagement surfaces are located at opposing ends of the bottom plate.

11. The bioreactor vessel of claim 1 , further comprising:
at least one aperture formed in the bottom plate configured to allow for sensing of contents of the bioreactor vessel.

12. The bioreactor vessel of claim 1 , wherein:
the bottom plate includes a grid surface configured to provide support and gas exchange; and
wherein the bioreactor vessel further includes a gas-permeable, liquid impermeable membrane disposed above the bottom plate.

13. The bioreactor vessel of claim 12 , further comprising:
a feed port configured to facilitate the addition of a fluid into the interior compartment; and
a drain port configured to facilitate removal of used at least one of a fluid and/or cells from the cavity.

14. The bioreactor vessel of claim 13 , further comprising:
an air balance port formed in a top of the vessel body, the air balance port being configured to allow air to enter or exit the bioreactor vessel.

15. The bioreactor vessel of claim 13 , wherein:
the feed port and the drain port are located at opposing ends of the bioreactor vessel.

Assignees

• Global Life Sciences Solutions Usa Llc

Inventors

• Griffin Weston Blaine
• Corwin Alex D
• Zhang Xiaohua
• Smith Reginald Donovan
• Liu Zhen
• Zhang Chengkun
• Keskar Vandana
• Davis Brian Michael
• Shaikh Kashan

Classifications

• C12M23/24

  Gas permeable parts · CPC title

• C12M25/02

  Membranes; Filters (filters or filtration in general B01D24/00-B01D41/00) · CPC title

• C12M29/18

  External loop; Means for reintroduction of fermented biomass or liquid percolate (loop type reactors for chemical or physical processes B01J19/2435) · CPC title

• B01F31/23

  by pivoting the containers about an axis · CPC title

• C12M37/02 Primary

  Filters · CPC title