Neuro-chemical sensor with inhibition of fouling on nano-electrode

Patent metadata

Field	Value
Publication number	US-11370004-B2
Application number	US-201916695321-A
Country	US
Kind code	B2
Filing date	Nov 26, 2019
Priority date	May 23, 2017
Publication date	Jun 28, 2022
Grant date	Jun 28, 2022

Abstract

A biosensor includes an array of metal nanorods formed on a substrate. An electropolymerized conductor is formed over tops of a portion of the nanorods to form a reservoir between the electropolymerized conductor and the substrate. The electropolymerized conductor includes pores that open and close responsively to electrical signals applied to the nanorods. A dispensing material is loaded in the reservoir to be dispersed in accordance with open pores.

First claim

What is claimed is:

1. A method for fabricating a biosensor, comprising:
forming nanorods on a metal layer, the nanorods being surrounded by a recessed conformal layer exposing at least a portion of the nanorods;
electropolymerizing a conductor on tops of nanorods exposed by recessing to form a reservoir between an electropolymerized conductor and the metal layer, the electropolymerized conductor including pores that open and close responsively to electrical signals applied to the nanorods; and
loading a dispensing material to be dispersed in the reservoir in accordance with open pores.

2. The method as recited in claim 1 , further comprising closing the pores for in vivo operation.

3. The method as recited in claim 2 , further comprising opening the pores to dispense the dispensing material.

4. The method as recited in claim 1 , wherein the electrical signals are pulsed to control an amount of dispensing material released.

5. The method as recited in claim 1 , wherein the dispensing material includes a cell growth inhibitor or a cell growth promoter.

6. The method as recited in claim 1 , wherein the electropolymerized conductor includes polypyrrole.

7. The method as recited in claim 1 , wherein the nanorods are grouped into a first region and a second region where the first region includes the electropolymerized conductor and the dispensing material, and a second region includes a sensing region.

8. The method as recited in claim 1 , wherein the first region inhibits biofouling in at least the first region.

9. The method as recited in claim 1 , wherein the first region inhibits biofouling in the first region and the second region.

10. The method as recited in claim 1 , wherein the dispensing material can be dispersed two or more times.

11. A method for fabricating a biosensor, comprising:
forming nanorods on a metal layer, the nanorods being surrounded by a recessed conformal layer exposing at least a portion of the nanorods;
forming a reservoir between a conductor on tops of the nanorods exposed by recessing the conformal layer and the metal layer, the reservoir being between the metal layer and pores of the conductor that open and close responsively to electrical signals applied to the nanorods; and
loading a dispensing material to be dispersed in the reservoir in accordance with open pores.

12. The method as recited in claim 11 , further comprising closing the pores for in vivo operation.

13. The method as recited in claim 12 , further comprising opening the pores to dispense the dispensing material.

14. The method as recited in claim 11 , wherein the electrical signals are pulsed to control an amount of dispensing material released.

15. The method as recited in claim 11 , wherein the dispensing material includes a cell growth inhibitor or a cell growth promoter.

16. The method as recited in claim 11 , wherein the reservoir includes polypyrrole.

17. The method as recited in claim 11 , wherein the nanorods are grouped into a first region and a second region where the first region includes the reservoir and the dispensing material, and a second region includes a sensing region.

18. The method as recited in claim 11 , wherein the first region inhibits biofouling in at least the first region.

19. The method as recited in claim 11 , wherein the first region inhibits biofouling in the first region and the second region.

20. The method as recited in claim 11 , wherein the dispensing material can be dispersed two or more times.

Assignees

• IBM

Inventors

• Holmes Steven J
• Kinser Emily R
• Lin Qinghuang
• Marchack Nathan P
• Yu Roy R

Classifications

• A61B5/4839 Primary

  combined with drug delivery · CPC title

• B82Y40/00

  Manufacture or treatment of nanostructures · CPC title

• A61B2562/125

  characterised by the manufacture of electrodes · CPC title

• B82Y15/00

  Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors · CPC title

• B08B17/065

  the surface having a microscopic surface pattern to achieve the same effect as a lotus flower · CPC title