Neuro-stem cell stimulation and growth enhancement with implantable nanodevice

Patent metadata

Field	Value
Publication number	US-10583282-B2
Application number	US-201715811023-A
Country	US
Kind code	B2
Filing date	Nov 13, 2017
Priority date	Nov 13, 2017
Publication date	Mar 10, 2020
Grant date	Mar 10, 2020

Abstract

A nanodevice includes an array of metal nanorods formed on a substrate. An electropolymerized electrical conductor is formed over tops of a portion of the nanorods to form a reservoir between the electropolymerized conductor and the substrate. The electropolymerized conductor includes pores that open or close responsively to electrical signals applied to the nanorods. A cell loading region is disposed in proximity of the reservoir, and the cell loading region is configured to receive stem cells. A neurotrophic dispensing material is loaded in the reservoir to be dispersed in accordance with open pores to affect growth of the stem cells when in vivo.

First claim

What is claimed is:

1. A nanodevice, comprising:
an array of metal nanorods formed on a substrate;
an electropolymerized electrical conductor formed over tops of at least a portion of the nanorods to form a reservoir between the electropolymerized electrical conductor and the substrate, the electropolymerized electrical conductor including pores that open or close responsively to electrical signals applied to the nanorods;
a cell loading region disposed adjacent to the reservoir, the cell loading region being configured to receive stem cells; and
a neurotrophic dispensing material loaded in the reservoir to be dispersed in accordance with open pores to affect growth of the stem cells when in vivo.

2. The nanodevice as recited in claim 1 , wherein the electropolymerized electrical conductor includes electrically conductive polymers selected from the group consisting of polypyrrole, polyanilines, poly(thiophene), poly(3,4-ethylenedioxythiophene), poly(p-phenylene sulfide), poly(p-phenylene vinylene), poly(acetylene) and a combination thereof.

3. The nanodevice as recited in claim 1 , wherein the substrate includes a semiconductor material and further comprises a control circuit formed in the substrate to control activation of electrodes formed by the nanorods.

4. The nanodevice as recited in claim 1 , wherein the neurotrophic dispensing material includes a neurotrophin selected from the group consisting of brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4) and nerve growth factor (NGF).

5. The nanodevice as recited in claim 1 , wherein the electrical signals are pulsed to control an amount of neurotrophic dispensing material released.

Assignees

• IBM

Inventors

• Holmes Steven J
• Lin Qinghuang
• Kinser Emily R
• Marchack Nathan P
• Yu Roy R

Classifications

• A61N1/04 Primary

  Electrodes {(electrosurgical electrodes A61B18/14)} · CPC title

• A61N1/05

  for implantation or insertion into the body, e.g. heart electrode (A61N1/06 takes precedence) · CPC title

• A61N1/375

  Constructional arrangements, e.g. casings · CPC title

• B82Y15/00

  Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors · CPC title

• A61K38/185 Primary

  Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3 · CPC title