Hybrid telodendrimers

Patent metadata

Field	Value
Publication number	US-11369688-B2
Application number	US-201716332950-A
Country	US
Kind code	B2
Filing date	Sep 15, 2017
Priority date	Sep 15, 2016
Publication date	Jun 28, 2022
Grant date	Jun 28, 2022

Abstract

Methods and compositions are provided for hybrid telodendrimers and nanocarriers containing such hybrid telodendrimers.

First claim

What is claimed is:

1. A compound having the structure:

wherein
each L′ and L″ is independently a bond or a linker Ebes, aminocaproic acid, 5-aminopentanoic acid, 4-aminobutanoic acid, β-alanine, or succinic acid;
PEG is polyethene glycol and has a molecular weight of 1-50 kDa;
each R′ is independently selected from the group consisting of cholic acid, (3α, 5β, 7α, 12α)-7,12-dihydroxy-3-(2,3-dihydroxy-1-propoxy)-cholic acid (CA-4OH), (3α, 5β, 7α, 12α)-7-hydroxy-3,12-di(2,3-dihydroxy-1-propoxy)-cholic acid (CA-5OH), and (3α, 5β, 7α, 12α)-7,12-dihydroxy-3-(3-amino-2-hydroxy-1-propoxy)-cholic acid (CA-3OH—NH 2 );
each R″ is independently selected from the group consisting of biotin, trans-cinnamic acid, lauric acid, linoleic acid, lipoic acid, nicotinic acid, octanoic acid, oleic acid, retinoic acid, sorbic acid, piromidic acid, caffeic acid, ricinoleic acid, pantothenic acid, aminocaproic acid, riboflavin, pyridoxine, cholecalciferol, and a non-steroidal anti-inflammatory drug;
each branched monomer unit X is a diaminocarboxylic acid; and
each Y 1 is independently a crosslinkable group selected from the group consisting of a thiol, a boronic acid, a 1,2-diol, or a cysteine group.

2. The compound of claim 1 , wherein each branched monomer unit X is lysine.

3. The compound of claim 2 , wherein
each X is lysine;
PEG is PEG5k;
each R′ is Cholic acid; and
each R″ is selected from the group consisting of etodolac, indomethacin, naproxen, oxaprozin and sulindac.

4. The compound of claim 1 , wherein
each branched monomer unit X is lysine; and
each L′ is a linker Ebes or succinic acid.

5. The compound of claim 1 , wherein
each L″ is independently a bond or a linker Ebes;
PEG has a molecular weight of 1-50 kDa;
each R′ is cholic acid;
each R″ is selected from the group consisting of cinnamic acid and linoleic acid;
each branched monomer unit X is lysine; and
each Y 1 is cysteine.

Assignees

• Univ California

Inventors

• Lam Kit S
• Li Yuanpei
• Bharadwaj Gaurav

Classifications

• A61K47/549

  Sugars, nucleosides, nucleotides or nucleic acids · CPC title

• A61K31/192

  having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid  {(cannabinoids A61K31/658)} · CPC title

• A61K47/6907

  the form being a microemulsion, nanoemulsion or micelle · CPC title

• A61K9/5146 Primary

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides · CPC title

• A61K31/421

  1,3-Oxazoles, e.g. pemoline, trimethadione · CPC title