Reversibly crosslinked micelle systems

Patent metadata

Field	Value
Publication number	US-10106650-B2
Application number	US-201214117570-A
Country	US
Kind code	B2
Filing date	May 14, 2012
Priority date	May 13, 2011
Publication date	Oct 23, 2018
Grant date	Oct 23, 2018

Abstract

The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics.

First claim

What is claimed is:

1. A compound having the structure:

wherein
A is a monomer of lysine linked to the PEG group;
each X is lysine;
PEG is a polyethyleneglycol (PEG) polymer having a molecular weight of about 5 kDa;
each R is cholic acid;
L′ is a linker Ebes having the formula:

and
each Y 2 is cysteine.

Assignees

• Lam Kit S
• Li Yuanpei
• Luo Juntao
• Xiao Kai
• Univ California

Inventors

• Lam Kit S
• Li Yuanpei
• Luo Juntao
• Xiao Kai

Classifications

• A61P37/08

  Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14) · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• C08G83/004

  After treatment of dendrimers · CPC title

• C08L71/02

  Polyalkylene oxides · CPC title

• A61K9/1271

  Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers (liposomes as conjugates {A61K47/6911}) · CPC title