Compositions and methods for dental mineralization

Patent metadata

Field	Value
Publication number	US-11351193-B2
Application number	US-202016852983-A
Country	US
Kind code	B2
Filing date	Apr 20, 2020
Priority date	Jul 23, 2013
Publication date	Jun 7, 2022
Grant date	Jun 7, 2022

Abstract

The present invention relates to compositions for mineralizing a dental surface, in particular tooth enamel. Methods of mineralizing hypomineralized lesions (including subsurface lesions) in the tooth enamel caused by dental caries, dental corrosion and fluorosis are also provided. In particular, the invention relates to a method of mineralizing a dental surface or subsurface comprising contacting the dental surface or subsurface with a compound that is capable of increasing or maintaining the pH of a solution and a mineralizing agent.

First claim

The invention claimed is:

1. A method of mineralizing a dental surface or subsurface in a patient in need thereof, comprising
(i) contacting the dental surface or subsurface with a first composition comprising a mineralizing agent selected from one or more of stabilized amorphous calcium phosphate (ACP) and stabilized amorphous calcium fluoride phosphate (ACFP), and
(ii) subsequently to (i) and within 1 to 60 minutes of (i), contacting the dental surface or subsurface with a second composition comprising a base, thereby mineralizing a dental surface or subsurface.

2. A method according to claim 1 , wherein the dental surface is a lesion in enamel caused by caries, dental erosion or fluorosis.

3. A method according to claim 1 , wherein the stabilized amorphous calcium phosphate (ACP) and/or stabilized amorphous calcium fluoride phosphate (ACFP) is in a form selected from a toothpaste, toothpowder, liquid dentifrice, mouthwash, mouthrinse, mouth spray, varnish, dental cement, troche, chewing gum, lozenge, dental paste, gingival massage cream, gargle tablet, dairy product and other foodstuffs.

4. A method according to claim 1 , wherein the second composition is capable of maintaining the pH of a solution between 7 to 9.

5. A method according to claim 1 , wherein the second composition is capable of maintaining the pH of a solution at about 7.5.

6. A method according to claim 1 , wherein the second composition is provided in an amount effective to raise the pH of intra-lesion fluid of a dental lesion from 6 to 7.5.

7. A method according to claim 1 , wherein the base is selected from sodium bicarbonate, sodium hypochlorite, and urea.

8. A method according to claim 7 , wherein the second composition is in a form selected from a mouthrinse or mouthwash comprising sodium bicarbonate.

9. A method according to claim 1 , wherein the contacting of step (ii) is effected 1 to 30 minutes after the contacting of step (i).

10. A method according to claim 1 , wherein the contacting of step (ii) is effected 1 to 5 minutes after the contacting of step (i).

11. A method according to claim 1 , wherein the stabilized amorphous calcium phosphate (ACP) is casein phosphopeptide stabilized amorphous calcium phosphate (ACP).

12. A method according to claim 1 , wherein the stabilized amorphous calcium fluoride phosphate (ACFP) is casein phosphopeptide stabilized amorphous calcium fluoride phosphate (ACP).

13. A method according to claim 1 , wherein the base is sodium hydroxide.

Assignees

• Univ Melbourne

Inventors

• Reynolds Eric Charles

Classifications

• A61K8/21 Primary

  Fluorides; Derivatives thereof · CPC title

• A61K47/42

  Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein (oligopeptides having up to five amino acids {A61K47/183}; polyamino acids A61K47/34) · CPC title

• A61K9/0058

  Chewing gums (non-medicinal aspects, preparing chewing gum A23G4/00; chewing gum for care of the teeth or oral cavity, e.g. with breath freshener A61Q11/00) · CPC title

• A61K8/64

  Proteins; Peptides; Derivatives or degradation products thereof · CPC title

• A61P1/02

  Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis · CPC title