Stabilized calcium phosphate complexes

Patent metadata

Field	Value
Publication number	US-9295628-B2
Application number	US-201314077713-A
Country	US
Kind code	B2
Filing date	Nov 12, 2013
Priority date	Nov 25, 2004
Publication date	Mar 29, 2016
Grant date	Mar 29, 2016

Abstract

The present invention relates to a phosphopeptide-stabilized amorphous calcium phosphate and/or amorphous calcium fluoride phosphate complex, wherein the complex is formed at a pH of below 7.0. Methods of making such complexes are also provided. The complexes are useful in dental applications, in particular in dental remineralisation.

First claim

The invention claimed is:

1. A composition for dental restoration comprising a phosphopeptide stabilised amorphous calcium phosphate (ACP) or amorphous calcium fluoride phosphate (ACFP) complex, wherein the complex is formed at a pH of from about 5.0 up to but below 7.0, and wherein the ACP or ACFP complex has bound and unbound calcium, wherein the bound calcium in the complex is less than the bound calcium in an ACP or ACFP complex formed at a pH of 7.0 and the ACP or ACFP is predominantly in a basic form.

2. A composition according to claim 1 , further comprising a dental restorative material.

3. A composition according to claim 2 , wherein the dental restorative material is dental cement.

4. A composition according to claim 3 , wherein the dental cement is a glass ionomer cement.

5. A composition according to claim 1 , wherein the phosphopeptide stabilised amorphous calcium phosphate (ACP) or amorphous calcium fluoride phosphate (ACFP) complex is in an amount of 0.5 to 10% by weight of the composition.

6. A composition according to claim 1 , wherein the phosphopeptide stabilised amorphous calcium phosphate (ACP) or amorphous calcium fluoride phosphate (ACFP) complex is in an amount of 1 to 5% by weight of the composition.

7. A composition according to claim 1 , wherein the phosphopeptide includes the sequence Ser(P)-Ser(P)-Ser(P)-Glu-Glu wherein Ser(P) is phosphoserine and Glu is glutamic acid.

8. A composition according to claim 1 , wherein the phosphopeptide is a casein phosphopeptide.

9. A composition according to claim 1 , wherein the composition is in the form of a dentrifice, tooth gel, mouthwashes, trouches, dental pastes, gingival massage creams, gargle tablets, or other substantially liquid composition prior to application.

10. A composition according to claim 9 , wherein the phosphopeptide stabilised amorphous calcium phosphate (ACP) or amorphous calcium fluoride phosphate (ACFP) complex is about 2% by weight of the composition.

11. A composition according to claim 1 , wherein the composition is in the form of a mouthwash or mouthrinse.

Assignees

• Univ Melbourne

Inventors

• Reynolds Eric Charles

Classifications

• A61P1/02

  Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis · CPC title

• A61K38/00

  Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title

• A61K8/64 Primary

  Proteins; Peptides; Derivatives or degradation products thereof · CPC title

• A61K8/20

  Halogens; Compounds thereof · CPC title

• A61K8/24

  Phosphorous; Compounds thereof · CPC title