Structure of GII.4 norovirus protease—design of broad-spectrum protease inhibitors

Patent metadata

Field	Value
Publication number	US-11344600-B2
Application number	US-201716335349-A
Country	US
Kind code	B2
Filing date	Oct 5, 2017
Priority date	Oct 5, 2016
Publication date	May 31, 2022
Grant date	May 31, 2022

Abstract

The present disclosure concerns inhibitors of Norovirus protease that are suitable for use against any genotype of Norovirus, including at least GII.4 Norovirus proteases. In particular embodiments, specific compositions are encompassed, including their use for prevention or treatment of Norovirus infection in an individual.

First claim

What is claimed is:

1. A composition of matter, comprising compound 1076

2. A pharmaceutical composition, comprising the composition of claim 1 .

3. The pharmaceutical composition of claim 2 , wherein the composition is formulated in a cream, solution, pill, tablet, suppository, film, or enema.

4. A cleaning composition, comprising the composition of claim 1 .

5. The composition of claim 4 , wherein the composition is a solution or cream.

6. The composition of claim 4 , wherein the composition is in and/or on a substrate.

7. The composition of claim 6 , wherein the substrate is selected from the group consisting of a towel, a wipe, and a sponge.

Assignees

• Baylor College Medicine

Inventors

• Prasad B Venkataram
• Estes Mary K
• Song Yongcheng

Classifications

• A61K31/407

  condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A01N37/46

  N-acyl derivatives · CPC title

• A61P31/14

  for RNA viruses · CPC title

• G16C20/50

  Molecular design, e.g. of drugs · CPC title