Sample plate for laser desorption/ionization mass spectrometry

Patent metadata

Field	Value
Publication number	US-11322339-B2
Application number	US-201916689409-A
Country	US
Kind code	B2
Filing date	Nov 20, 2019
Priority date	Feb 21, 2019
Publication date	May 3, 2022
Grant date	May 3, 2022

Abstract

The present invention provides a sample plate for laser desorption/ionization mass spectrometry, comprising: a hydrophilic thin film capable of absorbing a laser ray; and a water-repellent thin film comprising surface-hydrophobized nanoparticles and being stacked in a region other than a region to be a sample spot on a surface of the hydrophilic thin film, wherein a water contact angle of the water-repellent thin film is 120° or more.

First claim

What is claimed is:

1. A sample plate for laser desorption/ionization mass spectrometry, comprising:
a hydrophilic thin film capable of absorbing a laser ray; and
a water-repellent thin film comprising surface-hydrophobized nanoparticles having a structure in which a plurality of the nanoparticles are stacked on each other in a thickness direction of the water-repellent thin film, and the water-repellent thin film being located in a region other than a region to be a sample spot on a surface of the hydrophilic thin film, wherein
a water contact angle of the water-repellent thin film is 120° or more.

2. The sample plate for laser desorption/ionization mass spectrometry according to claim 1 , wherein
the hydrophilic thin film is an organic silica thin film which is composed of organic silica having an organic group capable of absorbing a laser ray in a skeleton.

3. The sample plate for laser desorption/ionization mass spectrometry according to claim 2 , wherein
the organic silica thin film is a porous film having a textured structure in which dent parts are formed of column-shaped pores.

4. The sample plate for laser desorption/ionization mass spectrometry according to claim 1 , wherein
the water contact angle of the water-repellent thin film is 130° or more.

5. The sample plate for laser desorption/ionization mass spectrometry according to claim 1 , wherein
the water contact angle of the water-repellent thin film is 150° or more.

6. The sample plate for laser desorption/ionization mass spectrometry according to claim 2 , wherein
the organic group capable of absorbing a laser ray is an organic group having an absorption local maximum wavelength in a wavelength range of 200 to 600 nm.

7. The sample plate for laser desorption/ionization mass spectrometry according to claim 2 , wherein
the organic group capable of absorbing a laser ray is at least one selected from the group consisting of triphenylamine optionally having a substituent, naphthalimide optionally having a substituent, pyrene optionally having a substituent, perylene optionally having a substituent, and acridone optionally having a substituent.

8. The sample plate for laser desorption/ionization mass spectrometry according to claim 2 , wherein
the organic group capable of absorbing a laser ray is at least one selected from the group consisting of triphenylamine optionally having a substituent, and naphthalimide optionally having a substituent.

9. The sample plate for laser desorption/ionization mass spectrometry according to claim 1 , wherein
an average particle diameter of the surface-hydrophobized nanoparticles is 50 to 500 nm.

10. The sample plate for laser desorption/ionization mass spectrometry according to claim 1 , wherein
the surface-hydrophobized nanoparticles are surface-hydrophobized silica nanoparticles having hydrophobic groups introduced on their surface.

11. The sample plate for laser desorption/ionization mass spectrometry according to claim 10 , wherein
the hydrophobic group is at least one selected from the group consisting of an alkyl group, a fluorinated alkyl group, an alkyl chloride group, and an alkyl bromide group.

12. The sample plate for laser desorption/ionization mass spectrometry according to claim 10 , wherein
the hydrophobic group is a fluorinated alkyl group.

Assignees

• Toyota Chuo Kenkyusho Kk

Inventors

• Mizoshita Norihiro
• Murase Masakazu
• Sasaki Yuri
• Goto Yasutomo

Classifications

• H01J49/0418 Primary

  for laser desorption, e.g. matrix-assisted laser desorption/ionisation [MALDI] plates or surface enhanced laser desorption/ionisation [SELDI] plates · CPC title

• H01J49/164

  Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI] (sample holders H01J49/0418) · CPC title

• B82Y30/00

  Nanotechnology for materials or surface science, e.g. nanocomposites · CPC title

• B32B2307/728

  Hydrophilic · CPC title

• H01J49/161

  using photoionisation, e.g. by laser · CPC title