Interleukin-10 receptor-2 peptides, antibodies, compositions, and methods of use thereof
US-2019077859-A1 · Mar 14, 2019 · US
US11319367B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11319367-B2 |
| Application number | US-201916596839-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 9, 2019 |
| Priority date | Mar 27, 2015 |
| Publication date | May 3, 2022 |
| Grant date | May 3, 2022 |
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Disclosed herein are methods of reducing a symptom of respiratory disease in a pre-weaned milk-fed mammal by orally administering an isolated antibody that specifically binds the interleukin-10 peptide or an anti-interleukin-10 antibody. Also included are methods of reducing mixing stress in human and non-human mammals by administering an isolated antibody that specifically binds the interleukin-10 peptide or an anti-interleukin-10 antibody. Further included are milk and food compositions including the interleukin-10 peptide or anti-interleukin-10 antibody.
Opening claim text (preview).
The invention claimed is: 1. A method of reducing a symptom of a bovine respiratory disease complex in a pre-weaned bovine, comprising orally administering to the pre-weaned bovine an effective amount of an egg yolk preparation comprising an isolated antibody that specifically binds an interleukin-10 peptide of SEQ ID NO:2, wherein said antibody is a polyclonal avian egg yolk IgY antibody preparation produced by inoculating laying hens with the interleukin-10 peptide of SEQ ID NO:2; wherein administration is initiated between birth and weaning, and wherein administration is performed at least once daily for a period of 7 days to 7 weeks; and wherein the symptom of bovine respiratory disease complex is increased fecal Cryptosporidium parvum , reduced weight gain, decreased fecal pH, or a combination thereof. 2. The method of claim 1 , wherein administration of the egg yolk preparation is stopped after the 7 day to 7 week period and is not restarted for 1 to 14 days. 3. The method of claim 1 , wherein the bovine is 56 days of age or younger. 4. The method of claim 1 , wherein the egg yolk preparation comprising the isolated antibody that specifically binds the interleukin-10 peptide is administered in a milk composition.
comprising antibodies · CPC title
Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues · CPC title
Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula · CPC title
Antiparasitic agents · CPC title
Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title
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