Dialysis system for mixing treatment fluid at time of use

Patent metadata

Field	Value
Publication number	US-11311657-B2
Application number	US-201916447415-A
Country	US
Kind code	B2
Filing date	Jun 20, 2019
Priority date	Jul 5, 2007
Publication date	Apr 26, 2022
Grant date	Apr 26, 2022

Abstract

A peritoneal dialysis system includes first and second concentrate sources in selective fluid communication with a medical fluid pumping cassette, the first and second concentrate sources holding first and second peritoneal dialysis concentrates, respectively; a pump actuator configured to cause the medical fluid pumping cassette to pump the first and second concentrates; and a processor and memory configured to (i) determine a cumulative volume of at least one of the first or second peritoneal dialysis concentrates pumped from the medical fluid pumping cassette by the pump actuator, (ii) compare the cumulative volume to a threshold, and (iii) if the cumulative volume is outside of the threshold, modify a subsequent stroke volume of at least one of the first or second pump chambers actuated by the pump actuator in an attempt to cause an updated cumulative volume for the at least one peritoneal dialysis concentrate to be within the threshold.

First claim

The invention is claimed as follows:

1. A peritoneal dialysis system comprising:
a medical fluid pumping cassette including a first pump chamber and a second pump chamber;
a first concentrate source in selective fluid communication with the medical fluid pumping cassette, the first concentrate source holding a first peritoneal dialysis concentrate;
a second concentrate source in selective fluid communication with the medical fluid pumping cassette, the second concentrate source holding a second peritoneal dialysis concentrate;
a pump actuator operable with the medical fluid pumping cassette to actuate the first pump chamber and the second pump chamber; and
a processor and memory configured to (i) determine a cumulative volume of at least one of the first or second peritoneal dialysis concentrates pumped from the medical fluid pumping cassette by the pump actuator, (ii) compare the cumulative volume to a threshold, and (iii) if the cumulative volume is outside of the threshold, modify a subsequent stroke volume of at least one of the first or second pump chambers actuated by the pump actuator in an attempt to cause an updated cumulative volume for the at least one peritoneal dialysis concentrate to be within the threshold.

2. The peritoneal dialysis system of claim 1 , wherein the first peritoneal dialysis concentrate is dextrose and the second peritoneal dialysis concentrate is bicarbonate.

3. The peritoneal dialysis system of claim 1 , wherein the first pump chamber and the second pump chamber each include a diaphragm that is moved to pump the first and second peritoneal dialysis concentrates.

4. The peritoneal dialysis system of claim 3 , wherein the pump actuator is a pneumatic pump actuator configured to pneumatically actuate the diaphragms of the first and second pump chambers, and wherein the stroke volume for one of the first or second concentrates is determined using Boyle's Law and multiple pressure measurements.

5. The peritoneal dialysis system of claim 3 , wherein the cumulative volume of at least one of the first or second peritoneal dialysis concentrates includes a cumulative volume pumped over multiple strokes of the diaphragms of the first and second pump chambers.

6. The peritoneal dialysis system of claim 1 , wherein the pump actuator actuates the first pump chamber and the second pump chamber such that the first and second concentrates are mixed in a mixer or a patient line downstream from the medical fluid pumping cassette.

7. The peritoneal dialysis system of claim 1 , wherein the cumulative volume includes a first cumulative volume for the first peritoneal dialysis concentrate and a second cumulative volume for the second peritoneal dialysis concentrate, and wherein comparing the cumulative volume to the threshold includes at least one of (i) subtracting the second cumulative volume from the first cumulative volume or (ii) subtracting the first cumulative value from the second cumulative volume.

8. The peritoneal dialysis system of claim 7 , wherein the threshold is a threshold volume difference, and wherein comparing the cumulative volume to the threshold includes at least one of (a) comparing a difference resulting from subtracting the second cumulative volume from the first cumulative volume to the threshold volume difference or (a) comparing a difference resulting from subtracting the first cumulative volume from the second cumulative volume to the threshold volume difference.

9. The peritoneal dialysis system of claim 1 , wherein the processor and memory are further configured to compare the cumulative volume to a total fill volume to determine if a fill phase provided by the dialysis system has been achieved.

10. The peritoneal dialysis system of claim 9 , wherein if the fill phase has not been achieved, then the modified and subsequent stroke volume of at least one of the first or second pump chambers is actuated by the pump actuator.

11. The peritoneal dialysis system of claim 1 , wherein the first and second concentrate sources being in selective fluid communication with the medical fluid pumping cassette includes being in selective communication via at least one valve of the medical fluid pumping cassette.

12. A dialysis system comprising:
a medical fluid pumping cassette including a first pump chamber and a second pump chamber, the first and second pump chambers each including a pumping diaphragm;
a first concentrate source in selective fluid communication with the medical fluid pumping cassette, the first concentrate source holding a first dialysis concentrate;
a second concentrate source in selective fluid communication with the medical fluid pumping cassette, the second concentrate source holding a second dialysis concentrate;
a pneumatic pump actuator operable with the medical fluid pumping cassette to pneumatically actuate the pumping diaphragms of the first pump chamber and the second pump chamber; and
a processor and memory configured to (i) preform an analysis based upon Boyle's Law to determine a cumulative volume of at least one of the first or second dialysis concentrates pumped from the medical fluid pumping cassette by the pneumatic pump actuator, (ii) compare the cumulative volume to a threshold, and (iii) if the cumulative volume is outside of the threshold, modify a subsequent stroke volume of at least one of the first or second pump chambers actuated by the pneumatic pump actuator in an attempt to cause an updated cumulative volume for the at least one dialysis concentrate to be within the threshold.

13. The dialysis system of claim 12 , wherein the analysis based upon Boyle's Law includes a before and after stroke pressure analysis.

14. The dialysis system of claim 12 , wherein the analysis based upon Boyle's Law includes a pressure decay analysis.

15. The dialysis system of claim 12 , wherein the analysis based upon Boyle's Law combines a first analysis including a before and after stroke pressure analysis and a second analysis including a pressure decay analysis.

16. The dialysis system of claim 12 , wherein the first and second concentrate sources being in selective fluid communication with the medical fluid pumping cassette includes being in selective communication via at least one valve of the medical fluid pumping cassette.

17. A peritoneal dialysis system comprising:
a medical fluid pumping cassette;
a first concentrate source in selective fluid communication with the medical fluid pumping cassette, the first concentrate source holding a first peritoneal dialysis concentrate;
a second concentrate source in selective fluid communication with the medical fluid pumping cassette, the second concentrate source holding a second peritoneal dialysis concentrate;
a pump actuator operable to cause the medical fluid pumping cassette to pump the first and second concentrates; and
a processor and memory configured to (i) determine a cumulative volume of at least one of the first or second peritoneal dialysis concentrates pumped from the medical fluid pumping cassette by the pump actuator, (ii) compare the cumulative volume to a threshold, and (iii) if the cumulative volume is outside of the threshold, modify a subsequent stroke volume of at least one of the first or second pump chambers actuated by the pump actuator in an attempt to cause an updated cumulative volume for the at least one peritoneal dialysis concentrate to be within the threshold.

18. The peritoneal dialysis system of claim 17 , wherein the medical fluid pumping cassette includes at least one pump chamber actuated by the pump actuator to pump t

Assignees

• Baxter Int
• Baxter Healthcare Sa

Inventors

• Childers Robert W
• Holmquist Kurt
• Hopping Peter A

Classifications

• A61M1/288

  Priming (priming in extracorporeal blood circuits A61M1/3643) · CPC title

• Y10S604/905

  Aseptic connectors or couplings, e.g. frangible, piercable · CPC title

• A61M2205/122

  using evacuated interfaces to enhance contact · CPC title

• A61M2209/084

  Supporting bases, stands for equipment · CPC title

• A61M1/287

  Dialysates therefor · CPC title