Method and arrangement for sterilization, in particular for the sterilization of an adsorber

Patent metadata

Field	Value
Publication number	US-9011765-B2
Application number	US-200913125344-A
Country	US
Kind code	B2
Filing date	Oct 22, 2009
Priority date	Oct 24, 2008
Publication date	Apr 21, 2015
Grant date	Apr 21, 2015

Abstract

A method and an arrangement for sterilizing, in particular for sterilizing an adsorber, which has an adsorber housing that is to be filled with an adsorbent, are such that, instead of the adsorbent-filled adsorber housing being sterilized, the adsorbent is sterilized in a separate container, which is dimensioned such that the adsorbent spreads out in a thin layer in the container. Together with the adsorber housing, the container for sterilizing the adsorbent forms a closed system, such that the adsorbent can be transferred into the adsorber housing without the need for an aseptic environment. The container for receiving the adsorbent is preferably a bag, in which the adsorbent spreads out in a thin layer when the bag is lying flat on a plane surface. Since the adsorbent in the bag spreads out in a thin layer, the sterilization requires only a relatively small dose of radiation, which cannot damage the adsorbent. The bag is irradiated with high-energy radiation, in particular ionizing radiation. The adsorbent is then transferred from the bag into the adsorber housing. During the transfer of the adsorbent into the adsorber housing, the air and/or excess liquid present in the adsorber housing is removed from the adsorber housing preferably into one or more empty bags.

First claim

The invention claimed is:

1. A method of sterilizing a material which is to be made available in a container, the method comprising:
filling a sterilization container with the material to be sterilized, the sterilization container being sized such that the material to be sterilized distributes itself in the sterilization container in a thin film or layer,
irradiating (i) the container in which the material is to be made available and (ii) the sterilization container with high-energy radiation to sterilize the material in the sterilization container, and transferring the material into the container in which the material is to be made available, the sterilization container and the container in which the material is to be made available forming a closed system.

2. The method according to claim 1 , wherein the material is a medication.

3. The method according to claim 2 , wherein the medication is a medication for infusion or a nutrient.

4. The method according to claim 1 , wherein the material to be sterilized is an adsorbent and the container in which the material is to be made available includes an adsorber housing configured to be filled with the adsorbent.

5. The method according to claim 4 , wherein the sterilization container is a bag.

6. The method according to claim 4 , wherein the adsorbent is transferred into the adsorber housing via a line which connects the sterilization container to the adsorber housing, the line being closed off after the transfer of the adsorbent.

7. The method according to claim 4 , wherein at least one of air or excess liquid/fluid situated in the adsorber housing is fed out of the adsorber housing.

8. The method according to claim 7 , wherein at least one of air or excess liquid/fluid disposed in the adsorber housing is transferred into a container connected to the adsorber housing via a line.

9. The method according to claim 8 , wherein the container for receiving at least one of air or liquid/fluid is a bag.

10. The method according to claim 4 , wherein the sterilization container is filled with a liquid/fluid adsorbent.

11. The method according to claim 4 , wherein the sterilization container is filled with an adsorbent in powder form.

12. The method according to claim 11 , wherein a liquid/fluid is transferred into the sterilization container.

13. The method according to claim 10 , wherein a flushing liquid/fluid is transferred into the sterilization container once the adsorbent has been transferred into the adsorber housing, and after the sterilization container has been flushed, the flushing liquid/fluid is transferred into the adsorber housing.

Assignees

• Rahn Holger
• Leinenbach Hans-Peter
• Kuhn Stefan
• Gerner Franz-Josef
• Fresenius Medical Care De Gmbh

Inventors

• Rahn Holger
• Leinenbach Hans-Peter
• Kuhn Stefan
• Gerner Franz-Josef

Classifications

• A61L2/081

  Gamma radiation · CPC title

• A61L2/087 Primary

  Particle radiation, e.g. electron-beam, alpha or beta radiation · CPC title

• A61L2103/05

  Living organisms or biological materials · CPC title

• A61M1/168

  Sterilisation or cleaning before or after use · CPC title

• A61L2/08

  Radiation · CPC title