Method of producing a microtube

Patent metadata

Field	Value
Publication number	US-11299822-B2
Application number	US-201715446228-A
Country	US
Kind code	B2
Filing date	Mar 1, 2017
Priority date	Oct 5, 2006
Publication date	Apr 12, 2022
Grant date	Apr 12, 2022

Abstract

A method of producing a microtube is provided. The method comprising co-electrospinning two polymeric solutions through co-axial capillaries to thereby produce the microtube, wherein a first polymeric solution of the two polymeric solutions is for forming a shell of the microtube and a second polymeric solution of the two polymeric solutions is for forming a coat over an internal surface of the shell, the first polymeric solution is selected solidifying faster than the second polymeric solution and a solvent of the second polymeric solution is selected incapable of dissolving the first polymeric solution. Also provided are electrospun microtubes.

First claim

The invention claimed is:

1. A method of producing a microtube, the method comprising: co-electrospinning two polymeric solutions through co-axial capillaries to thereby produce the microtube, wherein a first polymeric solution of said two polymeric solutions is for forming a shell of the microtube and a second polymeric solution of said two polymeric solutions is for forming a coat over an internal surface of said shell, said first polymeric solution is selected solidifying faster than said second polymeric solution and a solvent of said second polymeric solution is selected incapable of dissolving said first polymeric solution, wherein a thickness of said shell is from about 100 nm to about 20 micrometer, and wherein an internal diameter of the microtube is from about 50 nm to about 50 micrometer.

2. The method of claim 1 , wherein said co-electrospinning comprises a one-step co-electrospinning for producing the microtube.

3. The method of claim 1 , wherein a solvent of said first polymeric solution evaporates faster than a solvent of said second polymeric solution.

4. The method of claim 1 , wherein said electrospinning is effected using a rotating collector.

5. The method of claim 1 , wherein a solvent of said second polymeric solution is capable of evaporating through said internal surface of said shell.

6. The method of claim 1 , wherein said second polymeric solution is capable of wetting said internal surface of said shell.

7. The method of claim 1 , wherein a thickness of said shell is from about 200 nm to about 10 micrometer.

8. The method of claim 1 , wherein an internal diameter of the microtube is from about 50 nm to about 20 micrometer.

9. The method of claim 1 , wherein the method of claim 1 , wherein said second polymeric solution comprises a surface active polymer.

10. The method of claim 1 , wherein said first polymeric solution comprises polyethylene glycol (PEG).

11. The method of claim 1 , wherein said shell comprises pores.

12. The method of claim 1 , wherein said microtube is filled with a liquid.

13. The method of claim 12 , wherein said liquid is blood.

14. The method of claim 1 , wherein said first and said second polymeric solutions are biocompatible.

15. The method of claim 1 , wherein said first polymeric solution comprises a polymer selected from the group consisting of poly (e-caprolactone) (PCL), polyamide, poly(siloxane), poly(silicone), poly(ethylene), poly(vinyl pyrrolidone), poly(2-hydroxy ethylmethacrylate), poly(N-vinyl pyrrolidone), poly(methyl methacrylate), poly(vinyl alcohol), poly(acrylic acid), poly(vinyl acetate), polyacrylamide, poly(ethylene-co-vinyl acetate), poly(ethylene glycol), poly(methacrylic acid), polylactide, polyglycolide, poly(lactide-coglycolide), polyanhydride, polyorthoester, poly(carbonate), poly(acrylo nitrile), poly(ethylene oxide), polyaniline, polyvinyl carbazole, polystyrene, poly(vinyl phenol), polyhydroxyacid, poly(caprolactone), polyanhydride, polyhydroxyalkanoate, polyurethane, collagen, albumin, alginate, chitosan, starch and hyaluronic acid.

16. The method of claim 1 , wherein said second polymeric solution comprises a polymer selected from the group consisting of poly(acrylic acid), poly(vinyl acetate), polyacrylamide, poly(ethylene-co-vinyl acetate), poly(ethylene glycol), poly(methacrylic acid), polylactide polyglycolide, poly(lactide-coglycolide), polyanhydride, polyorthoester, poly(carbonate), poly(ethylene oxide), polyaniline, polyvinyl carbazole, polystyrene, poly(vinyl phenol), polyhydroxyacid, alginate, starch and hyaluronic acid.

Assignees

• Technion Res & Dev Foundation

Inventors

• Zussman Eyal
• Dror Yael
• Salalha Wael
• Avrahami Ron

Classifications

• B29C48/335

  Multiple annular extrusion nozzles in coaxial arrangement, e.g. for making multi-layered tubular articles · CPC title

• D01D5/0038

  the fibre formed by solvent evaporation, i.e. dry electro-spinning · CPC title

• A61F2/06

  Blood vessels · CPC title

• D01D5/0046

  the fibre formed by coagulation, i.e. wet electro-spinning · CPC title

• A61L27/56

  Porous materials, {e.g. foams or sponges} · CPC title