Hollow fiber membrane layer laminate and method of manufacturing hollow fiber membrane layer laminate

Patent metadata

Field	Value
Publication number	US-11278652-B2
Application number	US-201916359108-A
Country	US
Kind code	B2
Filing date	Mar 20, 2019
Priority date	Sep 30, 2016
Publication date	Mar 22, 2022
Grant date	Mar 22, 2022

Abstract

A hollow fiber membrane laminate that includes a plurality of hollow fiber membranes wound to form a plurality of layers in a cylinder shape. The hollow fiber membranes are wound around a central axis while reciprocating a feeding point of the hollow fiber membranes along a central axis. Hollow fiber membranes adjacent to each other in each respective layer are separated by a predetermined separation distance. A speed differential z is reduced for successive layers approaching an outer side of the cylinder to maintain the predetermined separation distance. The speed differential z has a value obtained by dividing a pitch of the hollow fiber membranes within a respective layer by a traverse reciprocating distance.

First claim

What is claimed is:

1. A method of manufacturing a hollow fiber membrane layer laminate comprised of a plurality of hollow fiber membranes forming a cylinder, the method comprising:
winding the hollow fiber membranes around a central axis of the cylinder while reciprocating a feeding point of the hollow fiber membranes in a central axis direction of the cylinder to laminate a plurality of hollow fiber membrane layers in a radial direction of the cylinder, wherein the hollow fiber membranes adjacent to each other within each layer are separated by a predetermined separation distance; and
reducing a speed differential z of the winding of the hollow fiber membranes for successive layers as the winding step approaches an outer side in the radial direction of the cylinder, wherein the speed differential z has a value obtained by dividing a pitch of the hollow fiber membranes within each respective layer of the cylinder by a traverse reciprocating distance of the cylinder;
wherein the hollow fiber membrane layers include an innermost first layer with a first speed differential z 1 and a first separation distance d 1 and a plurality of radially overlying layers each with a respective speed differential z and a respective separation distance d; and
wherein a respective ratio of d 1 to each respective overlying separation distance d is within a range from 0.8 to 1.2.

2. The method of manufacturing a hollow fiber membrane layer laminate according to claim 1 :
wherein a difference between the speed differentials z in the hollow fiber membrane layers adjacent to each other in the radial direction of the cylinder is within a range of 0.4% to 1.1%.

3. The method of manufacturing a hollow fiber membrane layer laminate according to claim 1 wherein the reduction of the speed differential z is a gradual reduction according to an increasing diameter of the cylinder, thereby providing a gradual increase of the pitch and reducing a variation of the separation distance d.

4. A hollow fiber membrane layer laminate for an oxygenator, comprising:
a plurality of hollow fiber membranes wound into a cylinder:
wherein the plurality of hollow fiber membranes form a laminate having a plurality of layers in a radial direction of the cylinder;
wherein the plurality of hollow fiber membranes within each respective layer are separated from each other by a predetermined separation distance; and
wherein a pitch of the hollow fiber membranes is successively reduced from an innermost layer of the cylinder to an outermost layer of the cylinder so that the predetermined separation distance is maintained throughout the layers;
wherein the layers include an innermost first layer with a first separation distance d 1 and a plurality of radially overlying layers each with a respective separation distance d; and
wherein a respective ratio of d 1 to each respective overlying separation distance d is within a range from 0.8 to 1.2.

5. The hollow fiber membrane layer laminate according to claim 4 :
wherein the predetermined separation distance is from 50 μm to 300 μm.

6. The hollow fiber membrane layer laminate according to claim 4 :
wherein the hollow fiber membranes have an outer diameter of 300 μm to 1,000 μm.

7. The hollow fiber membrane layer laminate according to claim 4 comprising a heat exchanger in which a heat medium passes through inside the hollow fiber membranes.

8. A hollow fiber membrane layer laminate for an oxygenator, comprising:
a plurality of hollow fiber membranes wound into a cylinder;
wherein the plurality of hollow fiber membranes form a laminate having a plurality of layers in a radial direction of the cylinder;
wherein the plurality of hollow fiber membranes within each respective layer are separated from each other by a separation distance; and
wherein a variation in the separation distance between successive layers is 20% or less in comparison with an innermost layer.

Assignees

• Terumo Corp

Inventors

• Hiraguchi Ryuji
• Gyoten Akira

Classifications

• B01D2313/221

  Heat exchangers · CPC title

• B01D63/0231

  using supporting structures, e.g. filaments for weaving mats · CPC title

• B01D63/026

  Wafer type modules or flat-surface type modules · CPC title

• A61M2207/00

  Methods of manufacture, assembly or production · CPC title

• A61M1/1698 Primary

  Blood oxygenators with or without heat-exchangers (intracorporal A61M1/1678; manufacturing of membranes therefor B01D67/00; semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi-permeable membranes characterised by their material B01D71/00) · CPC title