Neuroprotection by mitochondria-targeted metformin
US-9956233-B2 · May 1, 2018 · US
Modified mito-metformin compounds and methods of synthesis and use thereof
US11274114B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11274114-B2 |
| Application number | US-201515503827-A |
| Country | US |
| Kind code | B2 |
| Filing date | Aug 13, 2015 |
| Priority date | Aug 14, 2014 |
| Publication date | Mar 15, 2022 |
| Grant date | Mar 15, 2022 |
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- Title
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- Abstract
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Abstract
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The present invention provides mito-metformin compounds, pharmaceutical compositions thereof, and methods of using the mito-metformin compounds in the treatment of cancer.
First claim
Opening claim text (preview).
We claim: 1. A modified metformin compound according to the following structure: wherein n is an integer selected from 1-11. 2. The mito-metformin compound of claim 1 , wherein the mito-metformin is according to the following structure: n=1—Mito-Metformin-C 2 5—Mito-Metformin-C 6 9—Mito-Metformin-C 10 11—Mito-Metformin-C 12 . 3. The mito-metformin compound of claim 1 , wherein the mito-metformin compound is according to the following structure: 4. The mito-metformin compound of claim 1 , wherein the mito-metformin compound is according to the following structure: 5. The mito-metformin compound of claim 1 , wherein the mito-metformin compound is according to the following structure: 6. The Mito-Metformin compound of claim 1 , wherein the mito-metformin compound is according to the following structure: 7. A kit comprising at least one mito-metformin compound of claim 1 , a pharmaceutically acceptable carrier or diluent, and instructional material. 8. The kit of claim 7 , wherein the kit comprises at least one mito-metformin compound according to the following structure: wherein n is an integer selected from 1-11. 9. The kit of claim 7 , wherein the mito-metformin compound is selected from the group consisting of mito-metformin compounds according to the following structure: 10. A method of inhibiting tumor formation in a subject comprising administering to the subject a therapeutically effective amount of a composition comprising at least one Mito-Metformin compound of claim 1 . 11. The method of claim 10 , wherein the mito-metformin compound is selected from the group consisting of mito metformin compounds according to the following structure:
Assignees
Inventors
Classifications
- C07F9/5456Primary
Arylalkanephosphonium compounds · CPC title
Aromatic phosphonium compounds (P-C aromatic linkage) · CPC title
Quaternary compounds thereof · CPC title
Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon · CPC title
Pyridinium derivatives, e.g. pralidoxime, pyridostigmine · CPC title
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- What does patent US11274114B2 cover?
- The present invention provides mito-metformin compounds, pharmaceutical compositions thereof, and methods of using the mito-metformin compounds in the treatment of cancer.
- Who is the assignee on this patent?
- Medical College Wisconsin Inc, Univ Daix Marseille 1, Univ Iowa State Res Found Inc, and 1 more
- What technology area does this patent fall under?
- Primary CPC classification C07F9/5456. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 15 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).