DPEP-1 Binding Compositions and Methods of Use
US-2024108686-A1 · Apr 4, 2024 · US
Neuroprotection by mitochondria-targeted metformin
US9956233B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-9956233-B2 |
| Application number | US-201615294083-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 14, 2016 |
| Priority date | Oct 15, 2015 |
| Publication date | May 1, 2018 |
| Grant date | May 1, 2018 |
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- Title
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Abstract
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The present invention provides modified metformin compounds, particularly mito-metformin compounds, and pharmaceutical compositions thereof. Methods of using the compounds to provide neuroprotection and in the treatment and/or prevention of neurodegenerative diseases are also described.
First claim
Opening claim text (preview).
We claim: 1. A method for providing a subject in need thereof with neuroprotection, comprising administering to said subject a neuroprotective composition which includes an effective amount of the mito-metformin compound of the following structure, wherein n is selected from the group consisting of one (1), five (5), nine (9), and eleven (11). 2. The method of claim 1 , wherein the subject suffers from a neurodegenerative disease. 3. The method of claim 2 , wherein the subject suffers from a neurodegenerative disease selected from the group consisting of Parkinson's disease, Alzheimer's disease and other related neurological diseases. 4. The method of claim 1 , wherein the subject is a mammal. 5. The method of claim 4 , wherein the mammal is a human. 6. The method of claim 1 , wherein the administering to said subject the neuroprotective composition prevents, reduces or reverses neuronal cell death within the subject. 7. The method of claim 1 , wherein the method treats a neural injury in a subject having a neurodegenerative disease by administering an effective amount of the neuroprotection composition in order to treat the neural injury. 8. The method of claim 1 , wherein the neuroprotective composition is administered in an amount effective to prevent, reduce or treat at least one symptom in a subject suffering from a neurodegenerative disease. 9. The method of claim 8 , wherein the neurodegenerative disease is Parkinson's disease or Alzheimer's disease.
Assignees
Inventors
Classifications
- A61K31/662Primary
Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon · CPC title
Pyridinium derivatives, e.g. pralidoxime, pyridostigmine · CPC title
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Frequently asked questions
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- What does patent US9956233B2 cover?
- The present invention provides modified metformin compounds, particularly mito-metformin compounds, and pharmaceutical compositions thereof. Methods of using the compounds to provide neuroprotection and in the treatment and/or prevention of neurodegenerative diseases are also described.
- Who is the assignee on this patent?
- Univ Iowa State Res Found Inc, Medical College Wisconsin Inc
- What technology area does this patent fall under?
- Primary CPC classification A61K31/662. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue May 01 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).