Amplifier amplitude digital control for a mass spectrometer

Patent metadata

Field	Value
Publication number	US-11270874-B2
Application number	US-202016833712-A
Country	US
Kind code	B2
Filing date	Mar 30, 2020
Priority date	Mar 30, 2020
Publication date	Mar 8, 2022
Grant date	Mar 8, 2022

Abstract

Control of an amplitude of a signal applied to rods of a quadrupole is described. In one aspect, a mass spectrometer includes an amplifier circuit that causes a radio frequency (RF) signal to be applied to the rods of the quadrupole. A controller circuit can determine that the actual amplitude of the RF signal differs than the expected amplitude and, in response, identify current and past environmental and performance parameters to adjust the amplitude.

First claim

We claim:

1. A mass spectrometer, comprising:
a quadrupole mass analyzer;
an amplifier circuit configured to generate a first radio frequency (RF) signal based on an amplifier RF input signal;
a circuit configured to receive the first RF signal and generate a second RF signal applied to a pair of rods of the quadrupole mass analyzer;
an analog-to-digital converter (ADC) configured to receive the second RF signal and generate a digitized second RF signal; and
a controller circuit configured to:
receive the digitized second RF signal;
determine an actual amplitude of the second RF signal based on the digitized second RF signal;
determine that the actual amplitude of the second RF signal is different than an expected amplitude of the second RF signal;
determine current environmental and performance parameters of the mass spectrometer;
determine an amplitude correction to apply to the amplifier RF input signal based on the actual amplitude, the current environmental and performance parameters, and historical environmental and performance parameters;
adjust the amplifier RF input signal in accordance with the amplitude correction to cause the actual amplitude of the second RF signal to be adjusted towards the expected amplitude.

2. The mass spectrometer of claim 1 , wherein the current environmental parameters include a temperature of a component of the mass spectrometer.

3. The mass spectrometer of claim 2 , wherein the component is one or more of: an inductor of the resonant circuit, or one or both of the rods of the pair of rods of the quadrupole mass analyzer.

4. The mass spectrometer of claim 1 , wherein the current performance parameters include a mode of operation of the quadrupole mass analyzer.

5. The mass spectrometer of claim 1 , wherein the controller circuit is further configured to:
determine a DC voltage applied to one or both of the rods of the pair of rods of the quadrupole mass analyzer;
determine that the DC voltage is different than an expected DC voltage; and
adjust the DC voltage to be closer to the expected DC voltage.

6. The mass spectrometer of claim 5 , wherein adjusting the DC voltage to be closer to the expected DC voltage is based on the historical environmental and performance parameters.

7. The mass spectrometer of claim 1 , wherein the controller circuit is further configured to:
determine characteristics indicating how the resonant circuit is performing; and
adjust the second RF signal based on the determination of the characteristics indicating how the resonant circuit is performing.

8. The mass spectrometer of claim 7 , wherein determining the characteristics indicating how the resonant circuit is performing includes:
provide an impulse waveform to the amplifier circuit; and
determine a resonant frequency of the resonant circuit based on a frequency of the second RF signal generated in response to the impulse waveform.

9. The mass spectrometer of claim 1 , wherein the controller circuit includes digital logic implementing determination of the amplitude correction.

Assignees

• Thermo Finnigan Llc

Inventors

• Smith Johnathan W
• Quarmby Scott T
• Kreft Dustin J
• Senko Michael W

Classifications

• H01J49/42

  Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons · CPC title

• H01J49/4215

  Quadrupole mass filters (H01J49/4225 takes precedence) · CPC title

• H01J49/022 Primary

  Circuit arrangements, e.g. for generating deviation currents or voltages (regulating electric or magnetic variables in general, e.g. current, magnetic field G05F); Components associated with high voltage supply (high voltage supply per se H02M) · CPC title

• H03K3/023 Primary

  by the use of differential amplifiers or comparators, with internal or external positive feedback · CPC title

• H01J49/4225

  Multipole linear ion traps, e.g. quadrupoles, hexapoles · CPC title