Copolymer-comprising antimicrobial, cell culture, antithrombotic, or biopharmaceutical article

Patent metadata

Field	Value
Publication number	US-11246966-B2
Application number	US-201816639271-A
Country	US
Kind code	B2
Filing date	Aug 2, 2018
Priority date	Aug 15, 2007
Publication date	Feb 15, 2022
Grant date	Feb 15, 2022

Abstract

An antimicrobial article, a cell culture article, an antithrombotic article, or a biopharmaceutical article that can reduce adhesion of proteins, blood components, cells, or bacteria containing a copolymer that contains a polymerized unit (A) represented by —CH2—CHOH— and a polymerized unit (B) represented by —CH2—CX2—, wherein Xs are the same as or different from each other, and are each an alkyl group having a linear, branched, or cyclic structure, and optionally containing an oxygen atom between carbon atoms, an alkoxy group having a linear, branched, or cyclic structure, and optionally containing a hetero atom between carbon atoms, a siloxy group having a carbon number of 3 or greater, an ester group containing an aromatic ring or an alkyl group and having a linear, branched, or cyclic structure, or H, excluding those in which both Xs are H.

First claim

The invention claimed is:

1. A cell culture article comprising a copolymer,
the copolymer comprising:
a polymerized unit (A) represented by —CH 2 —CHOH—; and
a polymerized unit (B) represented by —CH 2 —CX 2 —, wherein Xs are the same as or different from each other, and are each selected from the group consisting of an alkyl group represented by —(CH 2 ) n CH 3 (wherein n is an integer of 0 to 16); an ester group represented by —O(C═O)R (wherein R is a C1-C19 hydrocarbon group); or H, excluding those in which both Xs are H,
wherein if one of the two Xs is H and the other X is the alkyl group, n is 2 or more,
wherein if both of the two Xs are the alkyl groups, n is 0 for one of the two Xs and n is 2 or more for the other X,
at least one of the two Xs is a group represented by the formula: —(CH 2 ) n CH 3 (wherein n is an integer of 2 to 16), and
wherein the copolymer is a saponified copolymer.

2. The article according to claim 1 ,
wherein the polymerized unit (A) and the polymerized unit (B) give a mole ratio (AB) of 5/95 to 95/5.

3. A copolymer comprising:
a polymerized unit (A) represented by —CH 2 —CHOH—; and
a polymerized unit (B-1) represented by —CH 2 —CX 2 —, wherein Xs are the same as or different from each other, and are each an alkyl group having a carbon number of 1 or greater, having a linear, branched, or cyclic structure, and
at least one of the two Xs is a group represented by the formula: —(CH 2 ) n CH 3 (wherein n is an integer of 2 to 16), and
wherein the copolymer is a saponified copolymer.

4. The cell culture article of claim 1 , wherein the article is a bag, a sheet, a film, a vial, a petri dish, or a flask.

Assignees

• National Univ Corporation Nara Institute Of Science And Technology
• Daikin Ind Ltd

Inventors

• Ando Tsuyoshi
• TOTANI Masayasu
• Tanihara Masao
• Shibutani Shota
• Tanaka Yoshito
• Kawabe Takuma
• Mohri Haruhiko

Classifications

• A61L29/085

  Macromolecular materials · CPC title

• A61L2430/20

  for reconstruction of the heart, e.g. heart valves · CPC title

• A61L2430/22

  for reconstruction of hollow organs, e.g. bladder, esophagus, urether, uterus · CPC title

• A61L29/16

  Biologically active materials, e.g. therapeutic substances {(A61L29/048 takes precedence)} · CPC title

• C12M3/00

  Tissue, human, animal or plant cell, or virus culture apparatus · CPC title